ArticleGenetics2007
Prediction of multilocus identity-by-descent.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- A model for family-based case-control studies of genetic imprinting and epistasis.Briefings in bioinformatics · 2014Article
- Bayesian model selection for multiple QTLs mapping combining linkage disequilibrium and linkage.Genetics research · 2014Article
- A fast expectation-maximum algorithm for fine-scale QTL mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2012Article
- Effect of family relatedness on characteristics of estimated IBD probabilities in relation to precision of QTL estimates.BMC genetics · 2010Article
- Linear models for joint association and linkage QTL mapping.Genetics, selection, evolution : GSE · 2009Article
- Whole population, genome-wide mapping of hidden relatedness.Genome research · 2009Article
- Estimation of pairwise identity by descent from dense genetic marker data in a population sample of haplotypes.Genetics · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have enabled exact prediction of probabilities of identity-by-descent (IBD) in random-mating populations for a few loci (up to four or so), with extension to more using approximate regression methods. Here we present a precise predictor of multiple-locus IBD using simple formulas based on exact results for two loci. In particular, the probability of non-IBD X(ABC) at each of ordered loci A, B, and C can be well approximated by X(ABC) = X(AB)X(BC)/X(B) and generalizes to X(123...k) = X(12)X(23...)X(k)(-1,k)/X(k-2), where X is the probability of non-IBD at each locus. Predictions from this chain rule are very precise with population bottlenecks and migration, but are rather poorer in the presence of mutation. From these coefficients, the probabilities of multilocus IBD and non-IBD can also be computed for genomic regions as functions of population size, time, and map distances. An approximate but simple recurrence formula is also developed, which generally is less accurate than the chain rule but is more robust with mutation. Used together with the chain rule it leads to explicit equations for non-IBD in a region. The results can be applied to detection of quantitative trait loci (QTL) by computing the probability of IBD at candidate loci in terms of identity-by-state at neighboring markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.