Trial reportNeurorehabilitation and neural repair
Validity of the walking scale for spinal cord injury and other domains of function in a multicenter clinical trial.
Trial report in Neurorehabilitation and neural repair. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- The efficacy of exoskeleton robotic training on ambulation recovery in patients with spinal cord injury: A meta-analysis.The journal of spinal cord medicine · 2024Pooled it
- Walking Ability Outcome Measures in Individuals with Spinal Cord Injury: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Current state of balance assessment during transferring, sitting, standing and walking activities for the spinal cord injured population: A systematic review.The journal of spinal cord medicine · 2020Pooled it
- Assessment of disability in patients with acute traumatic spinal cord injury: a systematic review of the literature.Journal of neurotrauma · 2011Pooled it
- Assessment of impairment in patients with acute traumatic spinal cord injury: a systematic review of the literature.Journal of neurotrauma · 2011Pooled it
- A systematic review of functional ambulation outcome measures in spinal cord injury.Spinal cord · 2008Pooled it
- Functional Electrical Stimulation Combined With Reactive Balance Training for Individuals With Incomplete Spinal Cord Injury: A Randomised Clinical Trial.Neurorehabilitation and neural repair · 2026Trial
- Dolutegravir Reduces Human T-Cell Lymphotropic Virus Type 1 Proviral Load and Improves Neurological Outcomes in a Phase 2 Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Trial
- Impact of High-Definition Cathodal tDCS Preconditioning on Enhancing the Therapeutic Efficacy of iTBS Combined With FES for Improving Walking Function in Patients With Spinal Cord Injury: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2026Trial
- Transcutaneous spinal cord stimulation combined with robotic-assisted body weight-supported treadmill training enhances motor score and gait recovery in incomplete spinal cord injury: a double-blind randomized controlled clinical trial.Journal of neuroengineering and rehabilitation · 2025Trial
- Short-term results of intrathecal injection of low-dose bupivacaine in outpatients with chronic low back and lower extremity pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Trial
- Placebo-controlled study of rTMS combined with LokomatExperimental brain research · 2016Trial
- The effect of impedance-controlled robotic gait training on walking ability and quality in individuals with chronic incomplete spinal cord injury: an explorative study.Journal of neuroengineering and rehabilitation · 2014Trial
- Spinal Cord Injury Functional Ambulation Profile: a preliminary look at responsiveness.Physical therapy · 2014Trial
- Early multidimensional mobility assessments for discriminating discharge-level ambulation and functional independence in subacute stroke inpatients: a retrospective cohort study.Journal of rehabilitation medicine · 2026Article
- Lower limb rehabilitation in chronic incomplete SCI: a randomized controlled trial protocol comparing combined TMS-tSCS neuromodulation vs. tSCS alone.Frontiers in neuroscience · 2026Article
- Feasibility and impact of a Water Specific Therapy program in individuals with subacute incomplete spinal cord injury: A non-randomized controlled trial.The journal of spinal cord medicine · 2025Article
- A Home-Based Balance Exercise Training Program with Intermittent Visual Deprivation for Persons with Chronic Incomplete Spinal Cord Injury: A Pilot Study on Feasibility, Acceptability, and Preliminary Outcomes.Sensors (Basel, Switzerland) · 2025Article
- Relationship of serial muscle ultrasound of rectus femoris and ambulatory recovery in patients with acute incomplete spinal cord injury: A prospective observational study.The journal of spinal cord medicine · 2025Observational
- Exploring the feasibility of combining transcutaneous electrical spinal cord stimulation and overground robotic exoskeleton for gait rehabilitation in patients with spinal cord injury.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
objectiveTo demonstrate criterion (concurrent and predictive) and construct validity of the Walking Index for Spinal Cord Injury (WISCI) scale and other walking measures in the Spinal Cord Injury Locomotor Trial (SCILT).
designProspective multicenter clinical trial of a walking intervention for patients with acute traumatic spinal cord injury (SCI). PARTICIPANTS/
methodsBody weight-supported treadmill training was compared to overground mobility training in 146 patients with incomplete SCI (C4 to L3) enrolled within 8 weeks of onset and treated for 12 weeks. Primary outcome measures were the Functional Independence Measure (FIM), 50-foot walking speed (50FW-S), and 6-minute walking distance (6MW-D), tested 3, 6, and 12 months after entry. Secondary measures were the Lower Extremity Motor Score (LEMS), Berg Balance Scale (BBS), WISCI, and FIM locomotor score (LFIM), assessed at 6 centers by blinded observers. Data for the 2 arms were combined since no significant differences in outcomes had been found.
resultsCorrelations with WISCI at 6 months were significant with BBS (r = .90), LEMS (r = .85), LFIM (r = .89), FIM (r = .77), 50FW-S (r = .85), and 6MW-D ( r = .79); similar correlations occurred at 3 and 12 months. Correlations of change scores from baseline WISCI were significant for change scores from baseline of LEMS/BBS/LFIM. Correlation of baseline LEMS and WISCI at 12 months were most significant (r = .73). The R(2) of baseline LEMS explained 57% of variability of WISCI levels at 3 months.
conclusionConcurrent validity of the WISCI scale was supported by significant correlations with all measures at 3, 6, and 12 months. Correlation of change scores supports predictive validity. The LEMS at baseline was the best predictor of the WISCI score at 12 months and explained most of the variance, which supported both predictive and construct validity. The combination of the LEMS, BBS, WISCI, 50FW-S, and LFIM appears to encompass adequate descriptors for outcomes of walking trials for incomplete SCI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.