ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 49 citations in OpenAlex.
- Zebrafish knockout models of atxn1a, atxn1b, and atxn1l reveal distinct and shared phenotypic and transcriptomic alterations.Human molecular genetics · 2026Article
- MiR-30a-5p mediates epileptogenesis in epilepsy models by targeting SOX4 to regulate the Wnt/β-catenin pathway.Epilepsia open · 2026Article
- The effect of SOX4 gene 3'UTR polymorphisms on osteoporosis.Journal of orthopaedic surgery and research · 2021Article
- Cerebellar Astrocytes: Much More Than Passive Bystanders In Ataxia Pathophysiology.Journal of clinical medicine · 2020Review
- More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons.International journal of molecular sciences · 2019Review
- The Molecular Pathway Regulating Bergmann Glia and Folia Generation in the Cerebellum.Cerebellum (London, England) · 2018Review
- Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Over-expression of Sox4 and β-catenin is associated with a less favorable prognosis of osteosarcoma.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation.Molecular brain · 2015Article
- Efficient and graded gene expression in glia and neurons of primary cerebellar cultures transduced by lentiviral vectors.Histochemistry and cell biology · 2015Article
- SOX4 expression is closely associated with differentiation and lymph node metastasis in oral squamous cell carcinoma.Medical molecular morphology · 2014Article
- Cardiac outflow tract development relies on the complex function of Sox4 and Sox11 in multiple cell types.Cellular and molecular life sciences : CMLS · 2014Article
- Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Epigenetic regulation of Sox4 during palate development.Epigenomics · 2013Article
- Article
- Blockade of SOX4 mediated DNA repair by SPARC enhances radioresponse in medulloblastoma.Cancer letters · 2012Article
- Ric-8a, a guanine nucleotide exchange factor for heterotrimeric G proteins, regulates bergmann glia-basement membrane adhesion during cerebellar foliation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Review
- Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22.Oncogene · 2011Article
- Developing central nervous system and vulnerability to platinum compounds.Chemotherapy research and practice · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sox proteins of group C are strongly expressed in the developing nervous system and have been associated with maturation of neurons and glia. Here, we overexpressed the group C protein Sox4 in transgenic mice under the control of the human GFAP promoter. Transgene expression was detected in radial glia and astrocytes throughout the CNS. The transgenic mice were ataxic and exhibited hydrocephaly as well as cerebellar malformations. In the cerebellum, fissures were not formed and neuronal layering was dramatically disturbed. Nevertheless, all neuronal cell types of the cerebellum were present as well as cells with characteristics of early radial glia, astrocytes, and oligodendrocytes. However, radial glia failed to migrate into the position normally taken by Bergmann glia and did not extend radial fibers toward the pial surface. The cerebellar malformations can therefore be explained by the absence of functional Bergmann glia. We conclude that Sox4 expression counteracts differentiation of radial glia and has to be downregulated before full maturation can occur.
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