ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Fast vesicle replenishment and rapid recovery from desensitization at a single synaptic release site.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed.
- Impact of Elovl5 Deficiency on Cerebellar Excitatory Synaptic Transmission in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Quantitative single-molecule analysis of assembly and CaCommunications biology · 2024Article
- Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Depolarization-induced bursts of miniature synaptic currents in individual synapses of developing cerebellum.The Journal of general physiology · 2023Article
- Differential Subcellular Distribution and Release Dynamics of Cotransmitted Cholinergic and GABAergic Synaptic Inputs Modify Dopaminergic Neuronal Excitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses.Frontiers in synaptic neuroscience · 2021Article
- Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization.Biophysical journal · 2020Article
- Direct imaging of rapid tethering of synaptic vesicles accompanying exocytosis at a fast central synapse.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Control of Presynaptic Parallel Fiber Efficacy by Activity-Dependent Regulation of the Number of Occupied Release Sites.Frontiers in systems neuroscience · 2019Article
- Developmental Increase of Neocortical Presynaptic EfficacyFrontiers in synaptic neuroscience · 2019Article
- What We Can Learn From Cumulative Numbers of Vesicular Release Events.Frontiers in cellular neuroscience · 2019Article
- Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Kinetic barriers to SNAREpin assembly in the regulation of membrane docking/priming and fusion.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Counting Vesicular Release Events Reveals Binomial Release Statistics at Single Glutamatergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing.Cerebellum (London, England) · 2016Article
- The ubiquitous nature of multivesicular release.Trends in neurosciences · 2015Review
- Implementation of linear sensory signaling via multiple coordinated mechanisms at central vestibular nerve synapses.Neuron · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
When the synaptic connection between two neurons consists of a small number of release sites, the ability to maintain transmission at high frequencies is limited by vesicle mobilization and by the response of postsynaptic receptors. These two properties were examined at single release sites between granule cells and stellate cells by triggering bursts of quantal events either with alpha-latrotoxin or with high-frequency trains of presynaptic activity. Bursts and evoked responses consisted of tens to hundreds of events with frequencies of up to hundreds per second. This indicates that single release sites can rapidly supply vesicles from a reserve pool to a release-ready pool. In addition, postsynaptic AMPA receptors recover from desensitization with a time constant of approximately 5 ms. Thus, even for synapses composed of a single release site, granule cells can effectively activate stellate cells during sustained high-frequency transmission because of rapid vesicle mobilization and fast recovery of AMPA receptors from desensitization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.