Evidence map›Paper›PMID 17507552›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007

Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury.

Giselle M Petzinger, John P Walsh, Garnik Akopian, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Patty Turnquist, Marta Vucković, Beth E Fisher, Daniel M Togasaki and 1 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 5 pooled it
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 5 syntheses or guidelines pooled it, 324 citations in OpenAlex.

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  3. Current Perspectives on Aerobic Exercise in People with Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Giselle M PetzingerDepartment of Neurology, The George and MaryLou Boone Center for Parkinson's Disease Research, University of Southern California, Los Angeles, California 90033, USA.
John P Walsh
Garnik Akopian
Elizabeth Hogg
Avery Abernathy
Pablo Arevalo
Patty Turnquist
Marta Vucković
Beth E Fisher
Daniel M Togasaki
Michael W Jakowec
University of Southern California · US

Funding

Glutamate-Dopamine Plasticity in Nigrostriatal Injury: Excerise Enhanced RecoveryR01NS044327 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAKOWEC, MICHAEL WALTER, WALSH, JOHN P · 2002 to 2010
$1.8M
NINDS NIH HHS R01 NS044327NINDS NIH HHS R01 NS44327-1
6 · The paper itself

Abstract

Studies have suggested that there are beneficial effects of exercise in patients with Parkinson's disease, but the underlying molecular mechanisms responsible for these effects are poorly understood. Studies in rodent models provide a means to examine the effects of exercise on dopaminergic neurotransmission. Using intensive treadmill exercise, we determined changes in striatal dopamine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse. C57BL/6J mice were divided into four groups: (1) saline, (2) saline plus exercise, (3) MPTP, and (4) MPTP plus exercise. Exercise was started 5 d after MPTP lesioning and continued for 28 d. Treadmill running improved motor velocity in both exercise groups. All exercised animals also showed increased latency to fall (improved balance) using the accelerating rotarod compared with nonexercised mice. Using HPLC, we found no difference in striatal dopamine tissue levels between MPTP plus exercise compared with MPTP mice. There was an increase detected in saline plus exercise mice. Analyses using fast-scan cyclic voltammetry showed increased stimulus-evoked release and a decrease in decay of dopamine in the dorsal striatum of MPTP plus exercise mice only. Immunohistochemical staining analysis of striatal tyrosine hydroxylase and dopamine transporter proteins showed decreased expression in MPTP plus exercise mice compared with MPTP mice. There were no differences in mRNA transcript expression in midbrain dopaminergic neurons between these two groups. However, there was diminished transcript expression in saline plus exercise compared with saline mice. Our findings suggest that the benefits of treadmill exercise on motor performance may be accompanied by changes in dopaminergic neurotransmission that are different in the injured (MPTP-lesioned) compared with the noninjured (saline) nigrostriatal system.

Indexed as

AnimalsBasal GangliaDisease Models, AnimalDopamineExercise TherapyMaleMiceMice, Inbred C57BLMotor ActivityMPTP PoisoningParkinson DiseaseSynaptic TransmissionDopamine

Identifiers

PMID17507552
PMCPMC6672356
OpenAlexW2078238654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.