ArticleJournal of clinical microbiology2007
Phylogenetic diversity and microsphere array-based genotyping of human pathogenic Fusaria, including isolates from the multistate contact lens-associated U.S. keratitis outbreaks of 2005 and 2006.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed.
- Virulence determinants of Fusarium oxysporum for clinical infections.PLoS pathogens · 2026Article
- Microbiological Spectrum, risk factors, and antifungal susceptibility of fungal keratitis in the Indore region of Central India.Indian journal of ophthalmology · 2026Article
- Members of theJournal of fungi (Basel, Switzerland) · 2026Article
- An Emerging Disease of Leaf Spot Caused by Paramyrothecium vignicola on Soybean in China.The plant pathology journal · 2026Article
- Atlas of hypocrealean invertebrate-pathogenic fungi of Thailand.Studies in mycology · 2026Article
- Integrated metabolomics and metagenomics uncover pathogenic mechanisms of Fusarium wilt and faba bean defense responses.NPJ science of food · 2026Article
- Revealing the Hidden Diversity of Aquatic and Terrestrial Fungi in Korea: 17 Newly Recorded Species.Mycobiology · 2026Article
- Morphology and multilocus phylogeny illuminate novel taxa inIMA fungus · 2026Article
- Host-specific adaptation inmBio · 2025Article
- Growth-Promoting Effects of Dark Septate Endophytes FungusJournal of fungi (Basel, Switzerland) · 2025Article
- Novel amplified fragment length polymorphism (AFLP) markers for typing medically relevantFungal systematics and evolution · 2025Article
- Identification of Fusarium oxysporum f. sp. melonis Race 2 in Central Taiwan and Its Potential Biocontrol Agent.The plant pathology journal · 2025Article
- Virulence ofbioRxiv : the preprint server for biology · 2025Article
- Causative Agents of Fungal Keratitis in Northeastern Iran: A 3-Year Tertiary Care Hospital Study.The American journal of tropical medicine and hygiene · 2025Article
- Antifungal susceptibility, clinical findings, and biofilm resistance of Fusarium species causing keratitis: a challenge for disease control.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Article
- Multi-locus molecular phylogenetic analysis reveals four new species and a new record ofMycoKeys · 2025Article
- Morpho-phylogenetic evidence reveals novel hyphomycetous fungi on medicinal plants in Southwestern China.Mycology · 2025Article
- Report of 10 Unrecorded Fungi from Freshwater Environment in Korea.Mycobiology · 2025Article
- Metarhizium mendonceae sp. nov.: An important biological control agent for insect pests.PloS one · 2025Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2005 and 2006, outbreaks of Fusarium keratitis associated with soft contact lens use occurred in multiple U.S. states and Puerto Rico. A case-control study conducted by the Centers for Disease Control and Prevention (CDC) showed a significant association between infections and the use of one particular brand of lens solution. To characterize the full spectrum of the causal agents involved and their potential sources, partial DNA sequences from three loci (RPB2, EF-1alpha, and nuclear ribosomal rRNA) totaling 3.48 kb were obtained from 91 corneal and 100 isolates from the patient's environment (e.g., contact lens and lens cases). We also sequenced a 1.8-kb region encoding the RNA polymerase II second largest subunit (RPB2) from 126 additional pathogenic isolates to better understand how the keratitis outbreak isolates fit within the full phylogenetic spectrum of clinically important fusaria. These analyses resulted in the most robust phylogenetic framework for Fusarium to date. In addition, RPB2 nucleotide variation within a 72-isolate panel was used to design 34 allele-specific probes to identify representatives of all medically important species complexes and 10 of the most important human pathogenic Fusarium in a single-well diagnostic assay, using flow cytometry and fluorescent microsphere technology. The multilocus data revealed that one haplotype from each of the three most common species comprised 55% of CDC's corneal and environmental isolates and that the corneal isolates comprised 29 haplotypes distributed among 16 species. The high degree of phylogenetic diversity represented among the corneal isolates is consistent with multiple sources of contamination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.