ArticleBMC genomics2007
Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 131 citations in OpenAlex.
- A Distinct Defense Strategy: The Molecular Basis of WSSV Tolerance inInternational journal of molecular sciences · 2026Article
- De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas ofAnimal cells and systems · 2026Article
- Investigating a novel β-glucan source to enhance disease resistance in Pacific white shrimp (Penaeus vannamei).Scientific reports · 2025Article
- Modulation of host lipid metabolism by virus infection leads to exoskeleton damage in shrimp.PLoS pathogens · 2024Article
- Role of Cellular Receptors in the Innate Immune System of Crustaceans in Response to White Spot Syndrome Virus.Viruses · 2022Review
- Shedding the Light onGenes · 2020Article
- The Protein-Protein Interaction Network ofFrontiers in physiology · 2019Article
- Article
- The State of "Frontiers in genetics · 2018Review
- Dystrophin gene expression and intracellular calcium changes in the giant freshwater prawn,Heliyon · 2017Article
- Molecular Characterization of Viral Responsive Protein 15 and Its Possible Role in Nuclear Export of Virus in Black Tiger Shrimp Penaeus monodon.Scientific reports · 2017Article
- Differential proteomics profiling of the ova between healthy and Rice stripe virus-infected female insects of Laodelphax striatellus.Scientific reports · 2016Article
- Molecular characterization of an adiponectin receptor homolog in the white leg shrimp, Litopenaeus vannamei.PeerJ · 2016Article
- Transcriptome Analysis of the Hepatopancreas in the Pacific White Shrimp (Litopenaeus vannamei) under Acute Ammonia Stress.PloS one · 2016Article
- ShrimpGPAT: a gene and protein annotation tool for knowledge sharing and gene discovery in shrimp.BMC genomics · 2014Article
- Transcriptome analysis of the initial stage of acute WSSV infection caused by temperature change.PloS one · 2014Article
- PmVRP15, a novel viral responsive protein from the black tiger shrimp, Penaeus monodon, promoted white spot syndrome virus replication.PloS one · 2014Article
- White Spot Syndrome Virus infection in Penaeus monodon is facilitated by housekeeping molecules.Journal of biosciences · 2013Article
- Sequencing and de novo analysis of the hemocytes transcriptome in Litopenaeus vannamei response to white spot syndrome virus infection.PloS one · 2013Article
- Transcriptome analysis on Chinese shrimp Fenneropenaeus chinensis during WSSV acute infection.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhite spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide. However, little information is available in terms of the molecular mechanisms of the host-virus interaction. In this study, we used an expressed sequence tag (EST) approach to observe global gene expression changes in white spot syndrome virus (WSSV)-infected postlarvae of Penaeus monodon.
resultsSequencing of the complementary DNA clones of two libraries constructed from normal and WSSV-infected postlarvae produced a total of 15,981 high-quality ESTs. Of these ESTs, 46% were successfully matched against annotated genes in National Center of Biotechnology Information (NCBI) non-redundant (nr) database and 44% were functionally classified using the Gene Ontology (GO) scheme. Comparative EST analyses suggested that, in postlarval shrimp, WSSV infection strongly modulates the gene expression patterns in several organs or tissues, including the hepatopancreas, muscle, eyestalk and cuticle. Our data suggest that several basic cellular metabolic processes are likely to be affected, including oxidative phosphorylation, protein synthesis, the glycolytic pathway, and calcium ion balance. A group of immune-related chitin-binding protein genes is also likely to be strongly up regulated after WSSV infection. A database containing all the sequence data and analysis results is accessible at http://xbio.lifescience.ntu.edu.tw/pm/.
conclusionThis study suggests that WSSV infection modulates expression of various kinds of genes. The predicted gene expression pattern changes not only reflect the possible responses of shrimp to the virus infection but also suggest how WSSV subverts cellular functions for virus multiplication. In addition, the ESTs reported in this study provide a rich source for identification of novel genes in shrimp.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.