ArticleJournal of clinical laboratory analysis2007
High-molecular intestinal alkaline phosphatase in chronic liver diseases.
Article in Journal of clinical laboratory analysis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 190 citations in OpenAlex.
- Tuning probe permeabilityChemical science · 2025Article
- Advances in the application of logic gates in nanozymes.Analytical and bioanalytical chemistry · 2024Review
- Construction of Aggregation-Induced Emission Molecule-MnONanomaterials (Basel, Switzerland) · 2023Article
- Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands.ACS applied materials & interfaces · 2023Article
- Protective Effect of Alkaline Phosphatase Supplementation on Infant Health.Foods (Basel, Switzerland) · 2022Review
- Fluorescent Biosensors Based on Silicon Nanowires.Nanomaterials (Basel, Switzerland) · 2021Review
- Copper nanocluster composites for analytical (bio)-sensing and imaging: a review.Mikrochimica acta · 2021Review
- Fluorescent enzyme-linked immunosorbent assay based on alkaline phosphatase-responsive coordination polymer composite.Mikrochimica acta · 2021Article
- Restoring the Oxidase-Like Activity of His@AuNCs for the Determination of Alkaline Phosphatase.Biosensors · 2021Article
- Sensitive Fluorescence Assay for the Detection of Alkaline Phosphatase Based on a CuSensors (Basel, Switzerland) · 2021Article
- A dual-mode resonance Rayleigh scattering and colorimetric alkaline phosphatase assay based onRSC advances · 2020Article
- Ultrasensitive Assay of Alkaline Phosphatase Based on the Fluorescent Response Difference of the Metal-Organic Framework Sensor.ACS omega · 2020Article
- Nanomaterials-Based Colorimetric Immunoassays.Nanomaterials (Basel, Switzerland) · 2019Review
- Determination of alkaline phosphatase activity based on enzyme-triggered generation of a thiol and the fluorescence quenching of silver nanoclusters.Mikrochimica acta · 2019Article
- Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells.Frontiers in chemistry · 2019Article
- Fluorometric determination of the activity of alkaline phosphatase based on the competitive binding of gold nanoparticles and pyrophosphate to CePOMikrochimica acta · 2018Article
- A sensitive fluorescent probe for alkaline phosphatase and an activity assay based on the aggregation-induced emission effect.RSC advances · 2018Article
- An impedimetric determination of alkaline phosphatase activity based on the oxidation reaction mediated by CuRSC advances · 2018Article
- Determination of the activity of alkaline phosphatase by using nanoclusters composed of flower-like cobalt oxyhydroxide and copper nanoclusters as fluorescent probes.Mikrochimica acta · 2018Article
- An Allosteric-Probe for Detection of Alkaline Phosphatase Activity and Its Application in Immunoassay.Frontiers in chemistry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of high-molecular intestinal alkaline phosphatase (HIALP) different from bone ALP detected in the alpha(2)beta region was recently clarified. In this study we used a novel method in which HIALP was detected after conversion to ALP(5) by protease to investigate the clinical significance of the appearance of HIALP in patients with chronic liver disease. The subjects were 241 patients with chronic liver disease. When a decrease in ALP(3) in the alpha(2)beta region and an increase in ALP(5) in the beta region were noted, the patient was judged HIALP-positive. In the patients with chronic liver disease, the total ALP activity (T-ALP) increased with progression of the pathology in the order of chronic hepatitis (CH), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). HIALP appeared in 22.4% and 49.3% of patients with CH and LC, respectively, but the positivity rate decreased to 30.4% in HCC. As autoimmune liver diseases, primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) were investigated. T-ALP was lower in PBC+AIH than in LC and HCC, but the HIALP-positive rate was high (44.4%). The HIALP-positive rate was dependent on ABO blood groups, and was high in blood groups B and O. In conclusion, the HIALP-positive rate was particularly high in patients with chronic liver disease, and was related to the pathological progression, which suggests that the method is clinically useful.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.