ArticleInternational journal of biological sciences2007
Human Maf1 negatively regulates RNA polymerase III transcription via the TFIIB family members Brf1 and Brf2.
Article in International journal of biological sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- RNA polymerase III is involved in regulatingeLife · 2024Article
- Article
- Lytic Infection with Murine Gammaherpesvirus 68 Activates Host and Viral RNA Polymerase III Promoters and Enhances Noncoding RNA Expression.Journal of virology · 2021Article
- Riddle of the Sphinx: Emerging Role of Transfer RNAs in Human Cancer.Frontiers in pharmacology · 2021Review
- tRNA Metabolism and Lung Cancer: Beyond Translation.Frontiers in molecular biosciences · 2021Review
- The MAF1 Phosphoregulatory Region Controls MAF1 Interaction with the RNA Polymerase III C34 Subunit and Transcriptional Repression in Plants.The Plant cell · 2020Article
- Maf1 Ameliorates Sepsis-Associated Encephalopathy by Suppressing the NF-Frontiers in immunology · 2020Article
- Article
- RNA Polymerase II Activity of Type 3 Pol III Promoters.Molecular therapy. Nucleic acids · 2018Article
- The dysregulation of tRNAs and tRNA derivatives in cancer.Journal of experimental & clinical cancer research : CR · 2018Review
- Topological organization and dynamic regulation of human tRNA genes during macrophage differentiation.Genome biology · 2017Article
- Tetrahelical structural family adopted by AGCGA-rich regulatory DNA regions.Nature communications · 2017Article
- The influence of the 5΄-terminal nucleotide on AgoshRNA activity and biogenesis: importance of the polymerase III transcription initiation site.Nucleic acids research · 2017Article
- The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability.Journal of molecular biology · 2017Article
- Mutation of nucleotides around the +1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage.Transcription · 2017Article
- Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.Genome research · 2016Article
- Gender Specific Differences in RNA Polymerase III Transcription.Journal of carcinogenesis & mutagenesis · 2016Article
- Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein.BMC cancer · 2015Article
- Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity.Journal of molecular biology · 2015Review
- Article
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA polymerase III (RNA pol III) transcribes many of the small structural RNA molecules involved in processing and translation, thereby regulating the growth rate of a cell. Initiation of pol III transcription requires the evolutionarily conserved pol III initiation factor TFIIIB. TFIIIB is the molecular target of regulation by tumor suppressors, including p53, RB and the RB-related pocket proteins. However, our understanding of negative regulation of human TFIIIB-mediated transcription by other proteins is limited. In this study we characterize a RNA pol III luciferase assay and further demonstrate in vivo that a human homolog of yeast Maf1 represses RNA pol III transcription. Additionally, we show that Maf1 repression of RNA pol III transcription occurs via TFIIIB, specifically through the TFIIB family members Brf1 and Brf2.
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