ArticleMolecular psychiatry2007
A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families.
Article in Molecular psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.Biomolecules · 2022Pooled it
- Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders.Cellular and molecular neurobiology · 2020Review
- Accelerated pseudogenization of trace amine-associated receptor genes in primates.Genes, brain, and behavior · 2019Article
- Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia.Schizophrenia research · 2017Article
- Transcriptome study of differential expression in schizophrenia.Human molecular genetics · 2013Article
- Parent-of-origin effects of FAS and PDLIM1 in attention-deficit/hyperactivity disorder.Journal of psychiatry & neuroscience : JPN · 2012Article
- Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus.Brain research · 2011Article
- Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs.BMC evolutionary biology · 2010Article
- Tailoring the definition of the clinical schizophrenia phenotype in linkage studies.Schizophrenia research · 2010Article
- The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.Schizophrenia research · 2009Article
- Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association.Journal of neuroscience research · 2008Article
- Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature.Current psychiatry reports · 2008Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
Abstract
The TAAR6 gene has been previously associated with schizophrenia in 192 pedigrees of European and African ancestry. To replicate these findings we performed an association study of TAAR6 in 265 pedigrees of the Irish Study of High-Density Schizophrenia Families (ISHDSF). Of the 24 genotyped single-nucleotide polymorphisms only rs12189813 and rs9389011 provided single-marker evidence for association (0.0094<or=P<or=0.03). Two-marker haplotypes (rs7772821 and rs12189813; 0.0071<or=P<or=0.0023) and four-marker haplotypes (rs8192622, rs7772821, rs12189813 and rs9389011; 0.0047<or=P<or=0.018) gave strongest evidence for association. The associated high-risk (HR) haplotype in the ISHDSF is defined by the major alleles at rs7772821 and rs12189813 (0.00097<or=P<or=0.023). The associated HR remains positive in a case only test of association by Operational Criteria score analysis in which significant association was observed only with the highest threshold for delusions (P<0.009). When analysis was restricted to affected individuals under the core schizophrenia (D2) diagnosis, the observed associations for HR were most significant in the highest threshold for delusions (P<0.004) and hallucinations (P<0.0004), supporting the family-based association with schizophrenia.
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