ArticlePhysiological genomics2007
Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21.
Article in Physiological genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 20 citations in OpenAlex.
- Systemic and proximal tubule specific knockout ofPhysiological genomics · 2026Article
- Spontaneous vascular dysfunction in Dahl salt-sensitive male rats raised without a high-salt diet.Physiological reports · 2024Article
- Brown-Norway chromosome 1 mitigates the upregulation of proinflammatory pathways in mTAL cells and subsequent age-related CKD in Dahl SS/JrHsdMcwi rats.American journal of physiology. Renal physiology · 2023Article
- Will the real Dahl S rat please stand up?American journal of physiology. Renal physiology · 2019Article
- Article
- Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD.Journal of the American Society of Nephrology : JASN · 2014Article
- A mutation in the start codon of γ-crystallin D leads to nuclear cataracts in the Dahl SS/Jr-Ctr strain.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Increased susceptibility to kidney injury by transfer of genomic segment from SHR onto Dahl S genetic background.Physiological genomics · 2012Article
- Increased Expression of Rififylin in A < 330 Kb Congenic Strain is Linked to Impaired Endosomal Recycling in Proximal Tubules.Frontiers in genetics · 2012Article
- Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models.Hypertension research : official journal of the Japanese Society of Hypertension · 2011Article
- Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy.American journal of physiology. Renal physiology · 2011Article
- Heterogeneous stock rats: a new model to study the genetics of renal phenotypes.American journal of physiology. Renal physiology · 2010Article
- Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats.Physiological genomics · 2010Article
- Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection.Seminars in nephrology · 2010Review
- Integrating human and rodent data to identify the genetic factors involved in chronic kidney disease.Journal of the American Society of Nephrology : JASN · 2010Review
- Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains.American journal of physiology. Renal physiology · 2009Article
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4 authors at 1 institution in 1 country.
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Abstract
Previously, we conducted a genome scan on a population derived from the Dahl salt-sensitive hypertensive (S) and the spontaneously hypertensive rat (SHR) using urinary albumin excretion (UAE) as our primary measure of renal function. We identified 10 quantitative trait loci (QTL) linked to several renal and/or cardiovascular traits. In particular, linkage and subsequent congenic strain analysis demonstrated that the loci on chromosome 2 had a large and significant effect on UAE compared with the S rat. The present work sought to characterize the chromosome 2 congenic strain [S.SHR] by conducting a time-course analysis (week 4-20), including evaluating additional renal parameters, histology, electron microscopy, and gene expression/ pathway analysis. Throughout the time course the congenic strain consistently maintained a threefold reduction in UAE compared with S rats and was supported by the histological findings of significantly reduced glomerular, tubular and interstitial changes. Gene expression/pathway analysis performed at week 4, 12, and 20 revealed that pathways involved in cellular assembly and organization, cellular movement, and immune response were controlled differently between the S and congenic. When all the data are considered, the chromosome 2 congenic appears to attenuate renal damage primarily through an altered fibrotic response. Recombinant progeny testing was employed to reduce the QTL to approximately 1.5 cM containing several interesting candidate genes. The concordance of this rat QTL with renal disease loci on human chromosome 1q21 demonstrate that elucidating the causative gene and mechanism of the rat QTL may be of particular importance for understanding kidney disease in humans.
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