ArticlePhysiological genomics2007
A genome-scale map of expression for a mouse brain section obtained using voxelation.
Article in Physiological genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain.Scientific reports · 2016Article
- Learning pair-wise gene functional similarity by multiplex gene expression maps.BMC bioinformatics · 2012Article
- Article
- Quantitative expression profile of distinct functional regions in the adult mouse brain.PloS one · 2011Article
- Candidate gene prioritization based on spatially mapped gene expression: an application to XLMR.Bioinformatics (Oxford, England) · 2010Article
- The use of neuroproteomics in drug abuse research.Drug and alcohol dependence · 2010Review
- Mining Association Rules among Gene Functions in Clusters of Similar Gene Expression Maps.IEEE International Conference on Bioinformatics and Biomedicine workshops. IEEE International Conference on Bioinformatics and Biomedicine · 2009Article
- Dual spatial maps of transcript and protein abundance in the mouse brain.Expert review of proteomics · 2009Review
- Analysis of multiplex gene expression maps obtained by voxelation.BMC bioinformatics · 2009Article
- Digital atlases as a framework for data sharing.Frontiers in neuroscience · 2008Article
- Quantitative methods for genome-scale analysis of in situ hybridization and correlation with microarray data.Genome biology · 2008Article
- Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: rodent longevity models for studying aging and calorie restriction.Current genomics · 2007Article
- Sharing and reusing gene expression profiling data in neuroscience.Neuroinformatics · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Gene expression signatures in the mammalian brain hold the key to understanding neural development and neurological diseases. We have reconstructed two-dimensional images of gene expression for 20,000 genes in a coronal slice of the mouse brain at the level of the striatum by using microarrays in combination with voxelation at a resolution of 1 mm3. Good reliability of the microarray results were confirmed using multiple replicates, subsequent quantitative RT-PCR voxelation, mass spectrometry voxelation, and publicly available in situ hybridization data. Known and novel genes were identified with expression patterns localized to defined substructures within the brain. In addition, genes with unexpected patterns were identified, and cluster analysis identified a set of genes with a gradient of dorsal/ventral expression not restricted to known anatomical boundaries. The genome-scale maps of gene expression obtained using voxelation will be a valuable tool for the neuroscience community.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.