ArticleGenes & development2007
Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.
Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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Who cites it
47 citing papers in PubMed.
- Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling.Current biology : CB · 2022Article
- A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint.EMBO reports · 2020Article
- Checkpoint Proteins Bub1 and Bub3 Delay Anaphase Onset in Response to Low Tension Independent of Microtubule-Kinetochore Detachment.Cell reports · 2019Article
- Location and functional analysis of the Aspergillus nidulans Aurora kinase confirm mitotic functions and suggest non-mitotic roles.Fungal genetics and biology : FG & B · 2017Article
- Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.Cell reports · 2017Article
- Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.PLoS genetics · 2016Article
- Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Molecular biology of the cell · 2014Article
- Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.Genetics · 2014Review
- Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.PloS one · 2014Article
- Review
- Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Chromosoma · 2013Review
- Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.Nature reviews. Molecular cell biology · 2013Review
- A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B.The Journal of cell biology · 2012Article
- Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.The Journal of cell biology · 2012Article
- Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint.Chromosoma · 2012Review
- Mitosis puts sisters in a strained relationship: force generation at the kinetochore.Experimental cell research · 2012Review
- A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.Genes & development · 2012Article
- Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.Current biology : CB · 2012Article
- Spindle assembly checkpoint: the third decade.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The spindle checkpoint delays anaphase onset until all chromosomes are correctly attached to microtubules. Ipl1 protein kinase (Aurora B) is required to correct inappropriate kinetochore-microtubule attachments and for the response to lack of tension between sister kinetochores. Here we identify residues in the checkpoint protein Mad3p that are phosphorylated by Ipl1p. When phosphorylation of Mad3p at two sites is prevented, the cell's response to reduced kinetochore tension is dramatically curtailed. Our data provide strong evidence for a distinct checkpoint pathway responding to lack of sister kinetochore tension, in which Ipl1p-dependent phosphorylation of Mad3p is a key step.
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Registered trials
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