ReviewCurrent allergy and asthma reports2007
Etiology of exercise-induced asthma: physical stress-induced transcription.
Review in Current allergy and asthma reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 21 citations in OpenAlex.
- The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma.Mediators of inflammation · 2016Review
- Exercise-induced bronchoconstriction: new evidence in pathogenesis, diagnosis and treatment.Asthma research and practice · 2015Review
- Exercise-induced asthma: critical analysis of the protective role of montelukast.Journal of asthma and allergy · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exercise-induced asthma (EIA) occurs with a high prevalence in both asthmatic and nonasthmatic individuals. Although understanding of the functional genomics (proteomics) in sports medicine remains limited, this review focuses on immunologic changes as reflected in transcriptional regulation in respect to EIA. Studies demonstrated that leukotrienes play a significant role in EIA. Exercise increases the distribution of leukotrienes and influences the leukotriene transcription pathway; it could be shown that the genes ALOX5 and ALOX5AP encoding for 5-lipooxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) as well as activators for 5-LO, p38 -mitogen-activated protein kinase (MAPK), and others, are enhanced after exercise in healthy subjects. Possibly EIA is triggered via leukotriene release if a predisposition or other conditions (eg, epithelial injury and repair) are present. Furthermore, exercise influences transcription factors such as nuclear factor-kappa B (NF-jB), activator protein-1 (AP1), cytokines, and chemokines and promotes cellular responses linked to EIA, which are possibly able to modify further the incidence or the severity of EIA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.