ArticleBMC cancer2007
BRIP1 (BACH1) variants and familial breast cancer risk: a case-control study.
Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pooled it
- Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population.Technology in cancer research & treatment · 2018Article
- Article
- No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.Journal of medical genetics · 2016Article
- The evolution of cancer risk assessment in the era of next generation sequencing.Journal of genetic counseling · 2014Article
- Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations.The Journal of biological chemistry · 2014Article
- Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature-based meta-analysis and meta-regression analysis.Experimental and therapeutic medicine · 2013Article
- The utility of copy number variation (CNV) in studies of hypertension-related left ventricular hypertrophy (LVH): rationale, potential and challenges.Molecular cytogenetics · 2013Article
- Genetic copy number variation and general cognitive ability.PloS one · 2012Article
- Investigation of modifier genes within copy number variations in Rett syndrome.Journal of human genetics · 2011Article
- Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.Future oncology (London, England) · 2011Review
- Article
- G-quadruplex nucleic acids and human disease.The FEBS journal · 2010Review
- Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families.British journal of cancer · 2009Article
- Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.Journal of human genetics · 2008Article
- Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies.PLoS genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInactivating and truncating mutations of the nuclear BRCA1-interacting protein 1 (BRIP1) have been shown to be the major cause of Fanconi anaemia and, due to subsequent alterations of BRCA1 function, predispose to breast cancer (BC).
methodsWe investigated the effect of BRIP1 -64G>A and Pro919Ser on familial BC risk by means of TaqMan allelic discrimination, analysing BRCA1/BRCA2 mutation-negative index patients of 571 German BC families and 712 control individuals.
resultsNo significant differences in genotype frequencies between BC cases and controls for BRIP1 -64G>A and Pro919Ser were observed.
conclusionWe found no effect of the putatively functional BRIP1 variants -64G>A and Pro919Ser on the risk of familial BC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.