ArticleInternational journal of experimental pathology2007
Reduced protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) in lymph node and liver metastases of gastric cancer.
Article in International journal of experimental pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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36 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Meta-Analysis of the Relationship between NM23 Expression to Gastric Cancer Risk and Clinical Features.BioMed research international · 2017Pooled it
- Review
- Kisspeptins inhibit human airway smooth muscle proliferation.JCI insight · 2022Article
- Tetraspanins: Novel Molecular Regulators of Gastric Cancer.Frontiers in oncology · 2021Review
- Negative Effect of Reduced NME1 Expression on Recurrence-Free Survival in Early Stage Non-Small Cell Lung Cancer.Journal of clinical medicine · 2020Article
- KISS1 in metastatic cancer research and treatment: potential and paradoxes.Cancer metastasis reviews · 2020Review
- The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis.International journal of molecular sciences · 2020Article
- Identification of the Prognosis-Related lncRNAs and Genes in Gastric Cancer.Frontiers in genetics · 2020Article
- Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma.OncoTargets and therapy · 2019Article
- Analysis of the association of the expression of KiSS-1 in colorectal cancer tissues with the pathology and prognosis.Oncology letters · 2018Article
- Value of CagA, HER2, ALDH1, and KiSS-1 in predicting metastasis and prognosis for gastric adenocarcinoma.International journal of clinical and experimental pathology · 2018Article
- Aberrant expression of ALDH1, MMP9, Integrin αvβ3, and KiSS-1 in invasive ductal carcinoma and their clinical significance.International journal of clinical and experimental pathology · 2018Article
- Clinical Implication and the Hereditary Factors of NM23 in Hepatocellular Carcinoma Based on Bioinformatics Analysis and Genome-Wide Association Study.Journal of oncology · 2018Article
- Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development.Frontiers in endocrinology · 2018Review
- Roles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal squamous cell carcinoma.World journal of surgical oncology · 2017Article
- G protein-coupled KISS1 receptor is overexpressed in triple negative breast cancer and promotes drug resistance.Scientific reports · 2017Article
- Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma.Diagnostic pathology · 2017Article
- The expression of metastasis-associated in colon cancer-1 and KAI1 in gastric adenocarcinoma and their clinical significance.World journal of surgical oncology · 2016Article
- Clinicopathological significance of KAI1 expression and epithelial-mesenchymal transition in non-small cell lung cancer.World journal of surgical oncology · 2015Article
- Metastasis suppressor NME1 regulates melanoma cell morphology, self-adhesion and motility via induction of fibronectin expression.Experimental dermatology · 2015Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMetastasis remains an incurable common complication in patients with gastric cancer. A variety of theories have been proposed to explain the inefficiency of the metastatic process. To compare protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) between primary tumours and metastatic tumours may be useful in illustrating these theories.
methodsMetastasis-related tissue microarrays (including normal tissues, primary tumours, nodal metastases and liver metastases) were constructed. The protein expression of nm23, KISS1, KAI1 and p53 in lymph node and liver metastases from advanced gastric cancer specimens was mainly examined by immunohistochemical staining in relation to primary tumours.
resultsImmunohistochemical staining showed reduced protein expression of nm23, KISS1 and KAI1 in lymph node and liver metastases compared with primary tumours. Results for p53 were to the contrary.
conclusionsOur investigations revealed a tendency of reduced protein expression of metastasis suppressor genes nm23, KISS1 and KAI1 in gastric cancer with the progress of metastasis. This means that the progression theory is an important determinant of metastatic efficiency.
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