ArticleAmerican journal of human genetics2007
A genomewide admixture map for Latino populations.
Article in American journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06860295 (The Architectural Immunoregulation in Atherosclerotic Disease), which is not on this map. Cited by 173 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Architectural Immunoregulation in Atherosclerotic Disease: A Single-Cell RNA Sequencing and Spatial Biology Approach
Who cites it
173 citing papers in PubMed, 3 syntheses or guidelines pooled it, 290 citations in OpenAlex.
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- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.PLoS genetics · 2011Pooled it
- The MYH9/APOL1 region and chronic kidney disease in European-Americans.Human molecular genetics · 2011Pooled it
- Variants in ARID5B gene are associated with the development of acute lymphoblastic leukemia in Mexican children.Annals of hematology · 2019Trial
- Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.Diabetes · 2010 · on this mapTrial
- The Landscape of Genomic and Socioeconomic Variables in Patients with Colorectal Cancer Based on Genetic Ancestry.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Scalable high resolution ancestry deconvolution for genomic data.Nature communications · 2026Article
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- A genealogy-based approach for revealing ancestry-specific structures in admixed populations.bioRxiv : the preprint server for biology · 2025Article
- Review
- A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.Cell genomics · 2024Article
- A general approach for inferring the ancestry of recent ancestors of an admixed individual.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry.Frontiers in oncology · 2024Article
- Diagnostic Performance of Serum MicroRNAs for ST-Segment Elevation Myocardial Infarction in the Emergency Department.Biomedicines · 2023Article
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- Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genomic and demographic processes differentially influence genetic variation across the human X chromosome.PloS one · 2023Article
- Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 11 institutions in 5 countries.
Funding
Abstract
Admixture mapping is an economical and powerful approach for localizing disease genes in populations of recently mixed ancestry and has proven successful in African Americans. The method holds equal promise for Latinos, who typically inherit a mix of European, Native American, and African ancestry. However, admixture mapping in Latinos has not been practical because of the lack of a map of ancestry-informative markers validated in Native American and other populations. To address this, we screened multiple databases, containing millions of markers, to identify 4,186 markers that were putatively informative for determining the ancestry of chromosomal segments in Latino populations. We experimentally validated each of these markers in at least 232 new Latino, European, Native American, and African samples, and we selected a subset of 1,649 markers to form an admixture map. An advantage of our strategy is that we focused our map on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. We evaluated the effectiveness of our map for localizing disease genes in four Latino populations from both North and South America.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.