Evidence map›Paper›PMID 17503104›Full record

Trial reportJournal of general internal medicine2007

Prevalence of depression-PTSD comorbidity: implications for clinical practice guidelines and primary care-based interventions.

Duncan G Campbell, Bradford L Felker, Chuan-Fen Liu, Elizabeth M Yano, JoAnn E Kirchner, Domin Chan, Lisa V Rubenstein, Edmund F Chaney

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of general internal medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 179 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00105820 nacompletednot on this map

Well-being Among Veterans Enhancement Study (WAVES)

TypeinterventionalSponsorUS Department of Veterans AffairsRan2003 to 2006Enrolled750ConditionsMajor Depression, PTSDArmsSystem level depression care quality improvement
NCT00119028 nawithdrawnnot on this map

Expanding and Testing VA Collaborative Care Models for Depression

TypeinterventionalSponsorUS Department of Veterans AffairsRan2005 to 2009Enrolled0ConditionsMajor Depression, Post-Traumatic Stress DisorderArmsDepression Care Quality Improvement Implementation
3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  6. Undetected post-traumatic stress disorder in secondary-care mental health services: systematic review.The British journal of psychiatry : the journal of mental science · 2018
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  13. MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
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119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Duncan G CampbellDepartment of Veterans Affairs, Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, Washington, USA. Duncan.Campbell@umontana.edu
Bradford L Felker
Chuan-Fen Liu
Elizabeth M Yano
JoAnn E Kirchner
Domin Chan
Lisa V Rubenstein
Edmund F Chaney

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCompared to those with depression alone, depressed patients with posttraumatic stress disorder (PTSD) experience more severe psychiatric symptomatology and factors that complicate treatment.

objectiveTo estimate PTSD prevalence among depressed military veteran primary care patients and compare demographic/illness characteristics of PTSD screen-positive depressed patients (MDD-PTSD+) to those with depression alone (MDD).

designCross-sectional comparison of MDD patients versus MDD-PTSD+ patients.

participantsSix hundred seventy-seven randomly sampled depressed patients with at least 1 primary care visit in the previous 12 months. Participants composed the baseline sample of a group randomized trial of collaborative care for depression in 10 VA primary care practices in 5 states. MEASUREMENTS: The Patient Health Questionnaire-9 assessed MDD. Probable PTSD was defined as a Primary Care PTSD Screen > or = 3. Regression-based techniques compared MDD and MDD-PTSD+ patients on demographic/illness characteristics.

resultsThirty-six percent of depressed patients screened positive for PTSD. Adjusting for sociodemographic differences and physical illness comorbidity, MDD-PTSD+ patients reported more severe depression (P < .001), lower social support (P < .001), more frequent outpatient health care visits (P < .001), and were more likely to report suicidal ideation (P < .001) than MDD patients. No differences were observed in alcohol consumption, self-reported general health, and physical illness comorbidity.

conclusionsPTSD is more common among depressed primary care patients than previously thought. Comorbid PTSD among depressed patients is associated with increased illness burden, poorer prognosis, and delayed response to depression treatment. Providers should consider recommending psychotherapeutic interventions for depressed patients with PTSD.

Indexed as

AgedComorbidityCross-Sectional StudiesFemaleHumansMajor Depressive DisorderMaleMiddle AgedPractice Guidelines as TopicPrevalencePrimary Health CareStress Disorders, Post-TraumaticVeterans

Identifiers

PMID17503104
PMCPMC2219856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.