ArticleChromosoma2007
Visualizing the dynamics of chromosome structure formation coupled with DNA replication.
Article in Chromosoma, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Calyculin A Induces Premature Chromosome Condensation and Chromatin Compaction in GbioRxiv : the preprint server for biology · 2025Article
- Foci-Xpress: Automated and Fast Nuclear Foci Counting Tool.International journal of molecular sciences · 2023Article
- Visualizing Active Replication Regions in S-Phase Chromosomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Chemical-Induced Premature Chromosome Condensation Protocol.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A Basic and Simple Chromosome Preparation Protocol.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos.Cell reports · 2015Article
- Generation of cell-based systems to visualize chromosome damage and translocations in living cells.Nature protocols · 2014Article
- Condensin II initiates sister chromatid resolution during S phase.The Journal of cell biology · 2013Article
- Linking abnormal mitosis to the acquisition of DNA damage.The Journal of cell biology · 2012Review
- Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry.Molecular biology of the cell · 2012Article
- Measurement of replication structures at the nanometer scale using super-resolution light microscopy.Nucleic acids research · 2010Article
- Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure.European biophysics journal : EBJ · 2009Article
- Unreplicated DNA in mitosis precludes condensin binding and chromosome condensation in S. cerevisiae.Frontiers in bioscience : a journal and virtual library · 2008Article
- Micromechanical studies of mitotic chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A basic question of cell biology is how DNA folds to chromosome. Numbers of examples have suggested the involvement of DNA replication in chromosome structure formation. To visualize and identify the dynamics of chromosome structure formation and to elucidate the involvement of DNA replication in chromosome construction, Cy3-2'-deoxyuridine-5'-triphosphate direct-labeled active replicating DNA was observed in prematurely condensed chromosomes (PCCs) under a confocal scanning microscope utilized with drug-induced premature chromosome condensation (PCC) technique that facilitates the visualization of interphase chromatin as condensed chromosome form. S-phase PCCs revealed clearly the drastic dynamics of chromosome formation that transits during S-phase from a 'cloudy nebula' to numerous numbers of 'beads on a string' and finally to 'striped arrays of banding structured chromosome' along with the progress of DNA replication. The number, distribution, and shape of replication foci were also measured in individual subphases of S-phase more precisely than reported previously; maximally, approximately 1,400 foci of 0.35 microm average radius size were scored at the beginning of the S-phase, and the number reduced to approximately 100 at the end of the S-phase. Drug-induced PCC clearly provided the new insight that eukaryote DNA replication is tightly coupled with the chromosome condensation/compaction for the construction of the higher-ordered structure of the eukaryote chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.