ReviewIntensive care medicine2007
Invasive candidiasis in pediatric intensive care patients: epidemiology, risk factors, management, and outcome.
Review in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Antibiotic regimens for late-onset neonatal sepsis.The Cochrane database of systematic reviews · 2021Pooled it
- Oral nystatin prophylaxis to prevent systemic fungal infection in very low birth weight preterm infants: a randomized controlled trial.BMC pediatrics · 2020Trial
- Neonatal Candida infections in Brazil: study on virulence and antifungal susceptibility with predominance of non-albicans Candida.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Observational
- Randomized controlled clinical trial of the impact of combined application of rhamnosus probiotics and oral nystatin on the colonization of intestinal Candida albicans in low birth weight neonates <2,500 grams.GMS hygiene and infection control · 2026Article
- Epidemiological characteristics of pediatric patients with invasive candidiasis in an intensive care unit in southwestern ColombiaBiomedica : revista del Instituto Nacional de Salud · 2025Observational
- An 11-Year retrospective analysis of candidiasis epidemiology, risk factors, and antifungal susceptibility in a tertiary care hospital in China.Scientific reports · 2025Article
- Comparing Fluconazole and Nystatin as Antifungal Prophylactics in Very Low Birth Weight Infants: A Randomized Clinical Trial.Oman medical journal · 2024Article
- Invasive fungal infections in critically ill children: epidemiology, risk factors and antifungal drugs.Drugs in context · 2024Review
- The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies.Antibiotics (Basel, Switzerland) · 2023Review
- Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature.Life (Basel, Switzerland) · 2023Review
- Invasive fungal infections in a paediatric intensive care unit in a low-to middle-income country.African journal of thoracic and critical care medicine · 2022Article
- Invasive fungal infections.African journal of thoracic and critical care medicine · 2022Article
- Probiotic Bacterial Application in Pediatric Critical Illness as Coadjuvants of Therapy.Medicina (Kaunas, Lithuania) · 2021Review
- Predicting Candida Infection in Pediatric Intensive Care Unit using Candida Score in a Low-Resource Setting.Global pediatric health · 2021Article
- Nutrition Support Practices of Hematopoietic Stem Cell Transplantation Centers in Mainland China.Current medical science · 2020Article
- InvasiveJournal of pediatric intensive care · 2020Article
- Antibiotic regimens for neonatal sepsis - a protocol for a systematic review with meta-analysis.Systematic reviews · 2019Article
- Zinc supplementation reducesJournal of clinical biochemistry and nutrition · 2019Article
- Persistent candidemia in very low birth weight neonates: risk factors and clinical significance.BMC infectious diseases · 2018Article
- Epidemiology of Candida albicans and non-C.albicans of neonatal candidemia at a tertiary care hospital in western China.BMC infectious diseases · 2017Article
Corrections and comments
- Erratum issuedPanteliadis, Christos P [added]
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of candidemia in pediatric patients follows the same pattern of increase as in adults, but the rate of increase is greater. Pediatric patients in critical condition, particularly young infants, are especially vulnerable to invasive Candida infections (ICI), partly because of their age and severe underlying disease and partly because of the invasive procedures used. DISCUSSION: Central venous catheters and arterial lines, parenteral nutrition, mechanical ventilation and extended use of antimicrobials enhance the risk of ICI. C. albicans continues to be the most prevalent isolate. However, an increasing role of non-C. albicans (NAC) spp., some of which are intrinsically or potentially resistant to antifungal agents, has been observed. NAC spp., particularly C. parapsilosis and C. tropicalis, account for almost half of ICI. The increased use of antifungals in immunocompromised patients, mainly prophylactically, is considered the strongest contributory factor to the changes in species distribution, which have subsequently affected the mortality and choice of empirical treatment.
conclusionsPrompt removal of lines and initiation of antifungal treatment are the milestones of management. Conventional amphotericin B remains a commonly used antifungal agent, but its lipid formulations and fluconazole are also used frequently. Novel antifungal agents such as second-generation triazoles and echinocandins exhibit potential as alternative agents in critically ill children with ICI. Although response rates are still far from satisfactory, improved understanding of risk factors, preventive strategies and new treatment options promise a better future outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.