ArticlePloS one2007
On the dynamics of the spontaneous activity in neuronal networks.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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118 citing papers in PubMed, 281 citations in OpenAlex.
- Effects of spatial constraints of inhibitory connectivity on the dynamical development of criticality in spiking networks.PLoS computational biology · 2026Article
- Critical neuronal avalanches arise from excitation-inhibition balanced spontaneous activity.iScience · 2026Article
- Network Analysis Pipeline for Neuronal 2D and 3D Organoid Multielectrode Recordings.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Symmetry breaking and avalanche shapes in modular neural networks.Frontiers in computational neuroscience · 2026Article
- Early life shifts in cortical inhibitory-excitatory balance underlies sensitive periods and skill development.Frontiers in cellular neuroscience · 2026Article
- Perimenopausal state oestradiol to progesterone imbalance drives Alzheimer's risk via ERRα dysregulation and energy dyshomeostasis.Nature communications · 2025Article
- Evaluating in-vivo spontaneous firing rate in the brain based on neuronal noise modeling.Communications biology · 2025Article
- Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- Macroscopic quantum effects in the brain: new insights into the fundamental principle underlying conscious processes.Frontiers in human neuroscience · 2025Article
- A high-density multi-electrode platform examining the effects of radiation on in vitro cortical networks.Scientific reports · 2024Article
- Prefrontal Excitation/ Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio.bioRxiv : the preprint server for biology · 2024Article
- The type of inhibition provided by thalamic interneurons alters the input selectivity of thalamocortical neurons.Current research in neurobiology · 2024Article
- Engineering the structural and electrical interplay of nanostructured Au resistive switching networks by controlling the forming process.Scientific reports · 2023Article
- Beyond pulsed inhibition: Alpha oscillations modulate attenuation and amplification of neural activity in the awake resting state.Cell reports · 2023Article
- Scale free avalanches in excitatory-inhibitory populations of spiking neurons with conductance based synaptic currents.Journal of computational neuroscience · 2023Article
- Article
- Empirical mode decomposition of local field potential data from optogenetic experiments.Frontiers in computational neuroscience · 2023Article
- From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.Translational psychiatry · 2022Review
- Disentangling the critical signatures of neural activity.Scientific reports · 2022Article
- A new method for training creativity: narrative as an alternative to divergent thinking.Annals of the New York Academy of Sciences · 2022Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most neuronal networks, even in the absence of external stimuli, produce spontaneous bursts of spikes separated by periods of reduced activity. The origin and functional role of these neuronal events are still unclear. The present work shows that the spontaneous activity of two very different networks, intact leech ganglia and dissociated cultures of rat hippocampal neurons, share several features. Indeed, in both networks: i) the inter-spike intervals distribution of the spontaneous firing of single neurons is either regular or periodic or bursting, with the fraction of bursting neurons depending on the network activity; ii) bursts of spontaneous spikes have the same broad distributions of size and duration; iii) the degree of correlated activity increases with the bin width, and the power spectrum of the network firing rate has a 1/f behavior at low frequencies, indicating the existence of long-range temporal correlations; iv) the activity of excitatory synaptic pathways mediated by NMDA receptors is necessary for the onset of the long-range correlations and for the presence of large bursts; v) blockage of inhibitory synaptic pathways mediated by GABA(A) receptors causes instead an increase in the correlation among neurons and leads to a burst distribution composed only of very small and very large bursts. These results suggest that the spontaneous electrical activity in neuronal networks with different architectures and functions can have very similar properties and common dynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.