ArticlePloS one2007
Application of broad-spectrum, sequence-based pathogen identification in an urban population.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Solid and Suspension Microarrays for Microbial Diagnostics.Methods in microbiology · 2015Article
- Review
- Evolving gene targets and technology in influenza detection.Molecular diagnosis & therapy · 2013Review
- Article
- Application of a broad-range resequencing array for detection of pathogens in desert dust samples from Kuwait and Iraq.Applied and environmental microbiology · 2011Article
- Reconstructed ancestral sequences improve pathogen identification using resequencing DNA microarrays.PloS one · 2010Article
- Application of broad-spectrum resequencing microarray for genotyping rhabdoviruses.Journal of virology · 2010Article
- VIPR: A probabilistic algorithm for analysis of microbial detection microarrays.BMC bioinformatics · 2010Article
- Broad spectrum respiratory pathogen analysis of throat swabs from military recruits reveals interference between rhinoviruses and adenoviruses.Microbial ecology · 2010Article
- Article
- Characterization of microbial pathogens by DNA microarrays.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Review
- Testing and validation of high density resequencing microarray for broad range biothreat agents detection.PloS one · 2009Article
- Universal detection and identification of avian influenza virus by use of resequencing microarrays.Journal of clinical microbiology · 2009Article
- Resequencing arrays for diagnostics of respiratory pathogens.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Resequencing microarray probe design for typing genetically diverse viruses: human rhinoviruses and enteroviruses.BMC genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A broad spectrum detection platform that provides sequence level resolution of target regions would have a significant impact in public health, case management, and means of expanding our understanding of the etiology of diseases. A previously developed respiratory pathogen microarray (RPM v.1) demonstrated the capability of this platform for this purpose. This newly developed RPM v.1 was used to analyze 424 well-characterized nasal wash specimens from patients presenting with febrile respiratory illness in the Washington, D. C. metropolitan region. For each specimen, the RPM v.1 results were compared against composite reference assay (viral and bacterial culture and, where appropriate, RT-PCR/PCR) results. Across this panel, the RPM assay showed >or=98% overall agreement for all the organisms detected compared with reference methods. Additionally, the RPM v.1 results provide sequence information which allowed phylogenetic classification of circulating influenza A viruses in approximately 250 clinical specimens, and allowed monitoring the genetic variation as well as antigenic variability prediction. Multiple pathogens (2-4) were detected in 58 specimens (13.7%) with notably increased abundances of respiratory colonizers (esp. S. pneumoniae) during viral infection. This first-ever comparison of a broad-spectrum viral and bacterial identification technology of this type against a large battery of conventional "gold standard" assays confirms the utility of the approach for both medical surveillance and investigations of complex etiologies of illness caused by respiratory co-infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.