Trial reportAnnals of internal medicine2007
The effect of a primary care practice-based depression intervention on mortality in older adults: a randomized trial.
Trial report in Annals of internal medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000367 (Prevention of Suicide in the Elderly), which is not on this map. Cited by 62 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Suicide in the Elderly
Who cites it
62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Pooled it
- Collaborative care for depression and anxiety problems.The Cochrane database of systematic reviews · 2012Pooled it
- Case identification of depression in patients with chronic physical health problems: a diagnostic accuracy meta-analysis of 113 studies.The British journal of general practice : the journal of the Royal College of General Practitioners · 2011Pooled it
- Use of antidepressants in late-life depression.Drugs & aging · 2008Pooled it
- Adapting psychotherapy in collaborative care for treating opioid use disorder and co-occurring psychiatric conditions in primary care.Families, systems & health : the journal of collaborative family healthcare · 2023Trial
- Treatment Adequacy and Adherence as Predictors of Depression Response in Primary Care.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Trial
- Assessing rates and contextual predictors of 5-year mortality among HIV-infected and HIV-uninfected individuals following HIV testing in Durban, South Africa.BMC infectious diseases · 2019Trial
- Integrating Depression Care Management into Medicare Home Health Reduces Risk of 30- and 60-Day Hospitalization: The Depression Care for Patients at Home Cluster-Randomized Trial.Journal of the American Geriatrics Society · 2016Trial
- Effect of collaborative care for depression on risk of cardiovascular events: data from the IMPACT randomized controlled trial.Psychosomatic medicine · 2014Trial
- A home-based intervention to reduce depressive symptoms and improve quality of life in older African Americans: a randomized trial.Annals of internal medicine · 2013Trial
- Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care.BMJ (Clinical research ed.) · 2013Trial
- Economic inequalities in the effectiveness of a primary care intervention for depression and suicidal ideation.Epidemiology (Cambridge, Mass.) · 2013Trial
- The effect of low-dose omega 3 fatty acids on the treatment of mild to moderate depression in the elderly: a double-blind, randomized, placebo-controlled study.European archives of psychiatry and clinical neuroscience · 2011Trial
- Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Trial
- Improving antidepressant adherence and depression outcomes in primary care: the treatment initiation and participation (TIP) program.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2010Trial
- The wish to die and 5-year mortality in elderly primary care patients.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2010Trial
- Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study.The American journal of psychiatry · 2009Trial
- Achieving effective antidepressant pharmacotherapy in primary care: the role of depression care management in treating late-life depression.Journal of the American Geriatrics Society · 2009Trial
- Primary care management of major depression in patients aged > or =55 years: outcome of a randomised clinical trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2008Trial
- Diabetes, depression, and death: a randomized controlled trial of a depression treatment program for older adults based in primary care (PROSPECT).Diabetes care · 2007Trial
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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- SummaryForPatientsIn
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFew studies have tested the effects of a depression intervention on the risk for death associated with depression.
objectiveTo test whether an intervention to improve depression care can modify the risk for death.
designPractice-based, randomized, controlled trial.
setting20 primary care practices in New York, New York, and Philadelphia and Pittsburgh, Pennsylvania. PATIENTS: 1226 randomly sampled patients identified through a 2-stage, age-stratified (60 to 74 years and > or =75 years) depression screening.
interventionDepression care manager working with primary care physicians to provide algorithm-based care. MEASUREMENTS: Depression status based on clinical interview and vital status at 5 years by using the National Death Index.
resultsAt baseline, 396 patients met criteria for major depression and 203 patients met criteria for clinically significant minor depression. After a median follow-up of 52.8 months, 223 patients died. Patients with depression in intervention practices were less likely to have died than those in usual care practices (adjusted hazard ratio, 0.67 [95% CI, 0.44 to 1.00]). Risk for death was reduced in patients with major depression (adjusted hazard ratio, 0.55 [CI, 0.36 to 0.84]) but not in patients with clinically significant minor depression (adjusted hazard ratio, 0.97 [CI, 0.49 to 1.92]). The benefit seemed to be almost entirely attributable to a reduction in deaths due to cancer. LIMITATIONS: The mechanism for an effect on deaths due to cancer is unclear. Depression status, cause of death, and vital status might have been misclassified.
conclusionsOlder primary care patients with major depression in practices that implemented depression care management were less likely to die over a 5-year period than were patients with major depression in usual care practices. The effect seemed to be limited to deaths due to cancer. The mechanism for such an effect is unclear and warrants further investigation. ClinicalTrials.gov registration number: NCT00000367.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.