ArticleProceedings of the National Academy of Sciences of the United States of America2007
Construction and behavior of engineered minichromosomes in maize.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- B chromosomes put the 'super' in supernumerary.Trends in genetics : TIG · 2026Review
- AI-Assisted Spatial Metabolic Engineering in Plants: Integrating Flux Design, Spatial Omics, and Synthetic Biology.Metabolites · 2026Review
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- Beyond genes: CRISPR/Cas9 for chromosomal engineering in polyploids.Frontiers in genome editing · 2026Article
- Past innovations and future possibilities in plant chromosome engineering.Plant biotechnology journal · 2025Review
- Can a plant biologist fix a thermostat?The New phytologist · 2025Review
- Recent advances in site-specific transgene insertion into the maize genome using recombinases and genome editing endonucleases.Frontiers in plant science · 2025Review
- Modular Assembly of Synthetic Secondary Chromosomes.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Editorial: Plant artificial chromosomes: progress and perspectives.Frontiers in plant science · 2023Article
- Biocircuits in plants and eukaryotic algae.Frontiers in plant science · 2022Review
- Artificial chromosome technology and its potential application in plants.Frontiers in plant science · 2022Review
- The supernumerary B chromosome of maize: drive and genomic conflict.Open biology · 2021Article
- Precise Characterization and Tracking of Stably Inherited Artificial Minichromosomes Made by Telomere-Mediated Chromosome Truncation inFrontiers in plant science · 2021Article
- Genetic and epigenetic effects on centromere establishment.Chromosoma · 2020Review
- James A. Birchler.The Plant cell · 2019Article
- Article
- OsARD4 encoding an acireductone dioxygenase improves root architecture in rice by promoting development of secondary roots.Scientific reports · 2018Article
- Analysis of B chromosome nondisjunction induced by the r-X1 deficiency in maize.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Article
- Plant artificial chromosome technology and its potential application in genetic engineering.Plant biotechnology journal · 2016Review
- Cytomolecular characterization and origin of de novo formed maize B chromosome variants.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Engineered minichromosomes were constructed in maize by modifying natural A and supernumerary B chromosomes. By using telomere-mediated chromosomal truncation, it was demonstrated that such an approach is feasible for the generation of minichromosomes of normal A chromosomes by selection of spontaneous polyploid events that compensate for the deficiencies produced. B chromosomes are readily fractionated by biolistic transformation of truncating plasmids. Foreign genes were faithfully expressed from integrations into normal B chromosomes and from truncated miniB chromosomes. Site-specific recombination between the terminal transgene on a miniA chromosome and a terminal site on a normal chromosome was demonstrated. It was also found that the miniA chromosome did not pair with its progenitor chromosomes during meiosis, indicating a useful property for such constructs. The miniB chromosomes are faithfully transmitted from one generation to the next but can be changed in dosage in the presence of normal B chromosomes. This approach for construction of engineered chromosomes can be easily extended to other plant species because it does not rely on cloned centromere sequences, which are species-specific. These platforms will provide avenues for studies on plant chromosome structure and function and for future developments in biotechnology and agriculture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.