ArticleNeurology2007
Comparison and predictors of rash associated with 15 antiepileptic drugs.
Article in Neurology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 276 citations in OpenAlex.
- Sex Differences in Adverse Effects of Antiseizure Medications in Adults with Epilepsy: A Systematic Review.CNS drugs · 2024Pooled it
- Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis.CNS drugs · 2021Pooled it
- HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.Neurology · 2017Pooled it
- Trial
- Risk factors and predictive score for phenytoin-induced cutaneous reactions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Population Pharmacokinetics and Model-Informed Precision Dosing of Clobazam Based on the Developmental and Genetic Characteristics of Children with Epilepsy.Pharmaceutics · 2025Article
- Hypersensitivity Reactions to Anticonvulsants.Current allergy and asthma reports · 2025Review
- Cutaneous Adverse Drug Reactions to Antiseizure Medications.Journal of epilepsy research · 2024Review
- Efficacy and safety of add-on antiseizure medications for focal epilepsy: A network meta-analysis.Epilepsia open · 2024Article
- Letter to Editor on Dual Anti-Epileptics Induced Stevens-Johnson Syndrome: A Case Report.JNMA; journal of the Nepal Medical Association · 2024Article
- Initiation of Antiseizure Medications by US Board-Certified Neurologists After a First Unprovoked Seizure Based on EEG Findings.Neurology. Clinical practice · 2024Article
- Evaluation of risk factors for recurrence of cutaneous adverse reactions due to anti-seizure medications in children: A retrospective study.Current journal of neurology · 2023Article
- Migraine management for the otolaryngologist.Laryngoscope investigative otolaryngology · 2023Review
- Kaleidoscopic Hues of Antiepileptics in Pediatric Population: Comparison of Prevailing Antiepileptics.Cureus · 2023Article
- A comprehensive review on pharmacological applications and drug-induced toxicity of valproic acid.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Review
- Exome sequencing allows detection of relevant pharmacogenetic variants in epileptic patients.The pharmacogenomics journal · 2022Article
- Lichenoid eruption: a hitherto unknown side effect of levetiracetam.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Treating Bipolar Disorder in Primary Care: Diagnosis, Pharmacology, and Management.International journal of general medicine · 2022Article
- HLA Risk Alleles in Aromatic Antiepileptic Drug-Induced Maculopapular Exanthema.Frontiers in pharmacology · 2021Article
- Adverse Skin Reactions with Antiepileptic Drugs Using Korea Adverse Event Reporting System Database, 2008-2017.Journal of Korean medical science · 2020Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine predictors and relative incidence of antiepileptic drug (AED)-related rash in patients taking all common AEDs.
methodsWe reviewed 1,890 outpatients. Eighty-one variables were tested as potential predictors of rash. We compared the rate of rash attributed to each AED (AED rash) with the average rate of rash attributed to the other AEDs in all adults (aged > or =16 years; n = 1,649) when taking carbamazepine (CBZ), clobazam (CLB), felbamate (FBM), gabapentin (GBP), lamotrigine (LTG), levetiracetam (LEV), oxcarbazepine (OXC), phenobarbital (PB), phenytoin (PHT), primidone (PRM), tiagabine (TGB), topiramate (TPM), vigabatrin (VGB), valproate (VPA), or zonisamide (ZNS). We repeated this analysis for patients with and without the identified nondrug predictors of AED rash.
resultsThe average rate of AED rash was 2.8%. The only nondrug predictor significant in multivariate analysis was occurrence of another AED rash (odds ratio 3.1, 95% CI 1.8 to 5.1; p < 0.0001); the rate of rash in this subgroup was 8.8%, vs 1.7% in those without another AED rash. Higher AED rash rates were seen with PHT (5.9% overall, p = 0.0008; 25.0% in those with another AED rash, p = 0.001), LTG (4.8%, p = 0.00095; 14.4%, p = 0.025), and CBZ (3.7%, not significant; 16.5%, p = 0.01). Lower rates were seen with LEV (0.6% overall; p = 0.00042), GBP (0.3%, p = 0.00035), and VPA (0.7%, p = 0.01). Rash rates were also low (<1% overall) with FBM, PRM, TPM, and VGB (not significant). These AED differences remained similar in patients with and without other AED rashes. There were four cases of Stevens-Johnson syndrome involving four AEDs.
conclusionsThe rate of an antiepileptic drug (AED) rash is approximately five times greater in patients with another AED rash (8.8%) vs those without (1.7%). Rash rates were highest with phenytoin, lamotrigine, and carbamazepine and low (<1%) with several AEDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.