ArticleThe Journal of cell biology2007
Myelin protein zero/P0 phosphorylation and function require an adaptor protein linking it to RACK1 and PKC alpha.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- On the synergy between myelin proteins P0, MBP, and P2 in peripheral nerve major dense line formation.The FEBS journal · 2025Article
- Tumor microenvironment (Part I): Tissue integrity in a rat model of peripheral neural cancer.Heliyon · 2024Article
- Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease.Neural regeneration research · 2023Review
- Neurodegenerative Disorder Risk in Krabbe Disease Carriers.International journal of molecular sciences · 2022Article
- Development of a common peroneal nerve injury model in domestic swine for the study of translational neuropathic pain treatments.Journal of neurosurgery · 2021Article
- Mechanisms and Treatments in Demyelinating CMT.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- How Does Protein Zero Assemble Compact Myelin?Cells · 2020Article
- Article
- Myelin protein zero mutations and the unfolded protein response in Charcot Marie Tooth disease type 1B.Annals of clinical and translational neurology · 2018Article
- Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm.AIMS genetics · 2018Article
- Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1.PloS one · 2014Article
- Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.Molecular psychiatry · 2010Article
- P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Myelin sheaths are formed with proteins that originated in vertebrate lineages.Neuron glia biology · 2008Article
- Features and functions of oligodendrocytes and myelin proteins of lower vertebrate species.Journal of molecular neuroscience : MN · 2008Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Point mutations in the cytoplasmic domain of myelin protein zero (P0; the major myelin protein in the peripheral nervous system) that alter a protein kinase Calpha (PKCalpha) substrate motif (198HRSTK201) or alter serines 199 and/or 204 eliminate P0-mediated adhesion. Mutation in the PKCalpha substrate motif (R198S) also causes a form of inherited peripheral neuropathy (Charcot Marie Tooth disease [CMT] 1B), indicating that PKCalpha-mediated phosphorylation of P0 is important for myelination. We have now identified a 65-kD adaptor protein that links P0 with the receptor for activated C kinase 1 (RACK1). The interaction of p65 with P0 maps to residues 179-197 within the cytoplasmic tail of P0. Mutations or deletions that abolish p65 binding reduce P0 phosphorylation and adhesion, which can be rescued by the substitution of serines 199 and 204 with glutamic acid. A mutation in the p65-binding sequence G184R occurs in two families with CMT, and mutation of this residue results in the loss of both p65 binding and adhesion function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.