ArticleMolecular and cellular biology2007
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- A novel linker region truncating variant in BCL10 underlies a leaky immunodeficiency phenotype.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Signaling through polymerization and degradation: Analysis and simulations of T cell activation mediated by Bcl10.PLoS computational biology · 2021Article
- TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO.Signal transduction and targeted therapy · 2021Article
- Role of IκB kinase β in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex.Biochemical and biophysical research communications · 2018Article
- Post-translational Modifications of the CARMA1-BCL10-MALT1 Complex in Lymphocytes and Activated B-Cell Like Subtype of Diffuse Large B-Cell Lymphoma.Frontiers in oncology · 2018Review
- Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease.Frontiers in immunology · 2018Review
- BCL10 - Bridging CARDs to Immune Activation.Frontiers in immunology · 2018Review
- Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Cold Spring Harbor molecular case studies · 2017Review
- BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair.Cell cycle (Georgetown, Tex.) · 2016Article
- Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.Molecular and cellular biology · 2015Article
- Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.Molecular systems biology · 2015Article
- The CBM signalosome: potential therapeutic target for aggressive lymphoma?Cytokine & growth factor reviews · 2014Review
- Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation.Molecular and cellular biology · 2013Article
- A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival.Molecular and cellular biology · 2013Article
- Identification of novel members reveals the structural and functional divergence of lepidopteran-specific Lipoprotein_11 family.Functional & integrative genomics · 2012Article
- Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB.Immunity · 2012Article
- Regulation of NF-κB by the CARD proteins.Immunological reviews · 2012Review
- The Ca2+-dependent phosphatase calcineurin controls the formation of the Carma1-Bcl10-Malt1 complex during T cell receptor-induced NF-kappaB activation.The Journal of biological chemistry · 2011Article
- NF-κB signaling pathways regulated by CARMA family of scaffold proteins.Cell research · 2011Review
- The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN.Molecular cell · 2010Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Bcl10 (B-cell lymphoma 10) is an adaptor protein comprised of an N-terminal caspase recruitment domain and a C-terminal serine/threonine-rich domain. Bcl10 plays a critical role in antigen receptor-mediated NF-kappaB activation and lymphocyte development and functions. Our current study has discovered that T-cell activation induced monophosphorylation and biphosphorylation of Bcl10 and has identified S138 within Bcl10 as one of the T-cell receptor-induced phosphorylation sites. Alteration of S138 to an alanine residue impaired T-cell activation-induced ubiquitination and subsequent degradation of Bcl10, ultimately resulting in prolongation of TCR-mediated NF-kappaB activation and enhancement of interleukin-2 production. Taken together, our findings demonstrate that phosphorylation of Bcl10 at S138 down-regulates Bcl10 protein levels and thus negatively regulates T-cell receptor-mediated NF-kappaB activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.