Evidence map›Paper›PMID 17502327›Full record

ArticleHeart (British Cardiac Society)2007

Left atrial Frank-Starling law assessed by real-time, three-dimensional echocardiographic left atrial volume changes.

Ashraf M Anwar, Marcel L Geleijnse, Osama I I Soliman, Attila Nemes, Folkert J ten Cate

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Article in Heart (British Cardiac Society), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Trial
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  14. Differences in Effects of Length-Dependent Regulation of Force and CaInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashraf M AnwarCardiology Department, Al-Husein University Hospital, Al-Azhar University, Cairo, Egypt.
Marcel L Geleijnse
Osama I I Soliman
Attila Nemes
Folkert J ten Cate

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Frank-Starling law describes the relation between left ventricular volume and function. However, only a few studies have described the relation between left atrial volume (LAV) and function.

objectiveTo describe an LA Frank-Starling law by studying changes in LAV measured by real-time, three-dimensional echocardiography (RT3DE).

methodsLAV was calculated by RT3DE in 70 patients at end-systole (LAV(max)), end-diastole (LAV(min)) and pre-atrial contraction (LAV(pre-A)). According to LAV(max), patients were classified into three groups: LAV(max) <50 ml (group I), LAV(max) 50-70 ml (group II) and LAV(max) >70 ml (group III). Calculated indices of LA pump function were active atrial stroke volume (SV), defined as LAV(pre-A) - LAV(min), and active atrial emptying fraction (EF), defined as active atrial SV/LAV(pre-A) x100%

resultsActive atrial SV was significantly higher in group II than in group I (mean (SD) 19.0 (9.2) vs 8.2 (4.9) ml, p<0.0001), in group III it was non-significantly lower than in group II (16.7 (12.5) vs 19.0 (9.2) ml). Active atrial SV correlated well with LAV(pre-A) (r = 0.56, p<0.001), but decreased with larger LAV(pre-A). Active atrial EF tended to be higher in group II than in group I (43.1 (18.2) vs 33.2 (17.5), p<0.10), in group III it was significantly lower than in group II (26.2 (18.5) vs 43.1 (18.2), p<0.01).

conclusionA Frank-Starling mechanism in the left atrium could be described by RT3DE, shown by an increase in LA contractility in response to an increase in LA preload up to a point, beyond which LA contractility decreased.

Indexed as

Models, CardiovascularAdultAtrial FunctionEchocardiography, Three-DimensionalFemaleHeartHeart AtriaHumansMaleMiddle AgedMyocardial ContractionObserver VariationStroke Volume

Identifiers

PMID17502327
PMCPMC2016907

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.