ArticleHeart (British Cardiac Society)2007
Selection bias resulting from the requirement for prior consent in observational research: a community cohort of people with ischaemic heart disease.
Article in Heart (British Cardiac Society), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Health disparities and selection bias in obtaining broad consent in a general practitioner setting.Frontiers in medicine · 2025Article
- Bias in obtaining broad consent in a German general practice? - Preliminary results from a cross-sectional study.Journal of family medicine and primary care · 2024Article
- Ownership of individual-level health data, data sharing, and data governance.BMC medical ethics · 2022Article
- The protocol of a clinical quality registry for dementia and mild cognitive impairment (MCI): the Australian dementia network (ADNeT) Registry.BMC geriatrics · 2020Article
- Interest in Research Participation Among Caregivers of Children with Neurodevelopmental Disorders.Journal of autism and developmental disorders · 2019Article
- Development of a binational thyroid cancer clinical quality registry: a protocol paper.BMJ open · 2019Article
- Parental opinions regarding consent for observational research of no or minimal risk in the pediatric intensive care unit.Journal of intensive care · 2019Article
- An Alternative Consent Process for Minimal Risk Research in the ICU.Critical care medicine · 2017Article
- A novel use of the Spine Tango registry to evaluate selection bias in patient recruitment into clinical studies: an analysis of patients participating in the Lumbar Spinal Stenosis Outcome Study (LSOS).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Power to the People: Data Citizens in the Age of Precision Medicine.Vanderbilt journal of entertainment and technology law · 2017Article
- Parental opinions regarding an opt-out consent process for inpatient pediatric prospective observational research in the US.Pragmatic and observational research · 2017Article
- Barbarians at the Gate: Consumer-Driven Health Data Commons and the Transformation of Citizen Science.American journal of law & medicine · 2016Article
- The importance of purpose: moving beyond consent in the societal use of personal health information.Annals of internal medicine · 2014Article
- Factors affecting maternal participation in the genetic component of the National Birth Defects Prevention Study-United States, 1997-2007.Genetics in medicine : official journal of the American College of Medical Genetics · 2014Article
- Electronic health records as a tool for recruitment of participants' clinical effectiveness research: lessons learned from tobacco cessation.Translational behavioral medicine · 2013Article
- Waiver of consent in noninterventional, observational emergency research: the PROMMTT experience.The journal of trauma and acute care surgery · 2013Article
- The effect of informed consent on results of a standard upper extremity intake questionnaire.The Journal of hand surgery · 2013Article
- LINKING SURVEY AND ADMINISTRATIVE RECORDS: MECHANISMS OF CONSENT.Sociological methods & research · 2012Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate differences between adults who consent to participate in observational research and those who do not.
designProspective, population-based cohort study.
setting35 randomised Irish general practices.
participants1609 adults with ischaemic heart disease identified in 2000-1.
interventionMedical records search, postal questionnaire and consent form in 2005-6.
main outcome measuresDifferences in demographic and prognostic risk factors between consenters and non-consenters.
resultsAt follow-up, charts were located for 1592 patients (98.9%). Questionnaires were sent to 1269 patients and 876 were returned (69%). Of these, 574 (65.5%) gave consent for participation in further research. Logistic regression identified four characteristics as independently positively predictive of consent to participation in further research among questionnaire responders: having undergone percutaneous transluminal coronary angioplasty was associated with an increased odds of consent, with an odds ratio (OR) of 1.77 (95% CI 1.09 to 2.86), as was a last recorded blood pressure <140/90 mm Hg (OR = 1.45 (1.00 to 2.09)), a last recorded total cholesterol level <5 mmol/l (OR = 1.71 (1.16 to 2.54)) and being an ex-smoker rather than a current smoker or non-smoker (OR = 1.73 (1.17 to 2.57)).
conclusionsThis research demonstrates the potential impact of consent bias in observational research on ischaemic heart disease, a disease of everyday clinical importance in Europe. It demonstrates that clinically important prognostic variables may be associated with consent preferences. Future cohorts, dependent upon prior written consent, may contain disproportionate numbers of those who have made healthy lifestyle decisions, have previously benefited from treatment or whose clinical risk factors are already well managed. As a result, the generalisability of such research may be diminished and the effects of treatments over- or underestimated.
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