ArticleBreast cancer research : BCR2007
Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis.
Article in Breast cancer research : BCR, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.Breast cancer research : BCR · 2016Pooled it
- Intrauterine environments and breast cancer risk: meta-analysis and systematic review.Breast cancer research : BCR · 2008Pooled it
- Article
- Associations of Early-Life and Adult Anthropometric Measures with the Expression of Stem Cell Markers CD44, CD24, and ALDH1A1 in Women with Benign Breast Biopsies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Obesity and cancer stem cells: Roles in cancer initiation, progression and therapy resistance.World journal of stem cells · 2023Review
- The association of women's birth size with risk of molecular breast cancer subtypes: a cohort study.BMC cancer · 2021Article
- Effect of excessive gestational weight on daughters' breast density at the end of puberty onset.Scientific reports · 2020Article
- The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.European journal of epidemiology · 2019Article
- Article
- The Obesity-Breast Cancer Conundrum: An Analysis of the Issues.International journal of molecular sciences · 2016Review
- Prenatal Maternal Physical Activity and Stem Cells in Umbilical Cord Blood.Medicine and science in sports and exercise · 2016Article
- Obesity, maternal smoking and SHBG in neonates.Diabetology & metabolic syndrome · 2016Article
- Size at birth and risk of breast cancer: update from a prospective population-based study.European journal of epidemiology · 2015Article
- Effect of preeclampsia on umbilical cord blood stem cells in relation to breast cancer susceptibility in the offspring.Carcinogenesis · 2015Article
- Role of IGF1R in Breast Cancer Subtypes, Stemness, and Lineage Differentiation.Frontiers in endocrinology · 2015Review
- Season of birth and other perinatal risk factors for melanoma.International journal of epidemiology · 2014Article
- The emerging role of insulin and insulin-like growth factor signaling in cancer stem cells.Frontiers in endocrinology · 2014Review
- Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioral development.Frontiers in endocrinology · 2014Review
- Exposures to synthetic estrogens at different times during the life, and their effect on breast cancer risk.Journal of mammary gland biology and neoplasia · 2013Review
- Implication of the Strand-Specific Imprinting and Segregation Model: IntegratingHereditary genetics : current research · 2013Article
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11 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionPrenatal levels of mitogens may influence the lifetime breast cancer risk by driving stem cell proliferation and increasing the number of target cells, and thereby increasing the chance of mutation events that initiate oncogenesis. We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential.
methodsWe analyzed cord blood samples from 289 deliveries. Levels of hormones and growth factors were correlated with concentrations of stem cell and progenitor populations (CD34+ cells, CD34+CD38- cells, CD34+c-kit+ cells, and granulocyte-macrophage colony-forming units). Changes in stem cell concentration associated with each standard deviation change in mitogens and the associated 95% confidence intervals were calculated from multiple regression analysis.
resultsCord blood plasma levels of insulin-like growth factor-1 (IGF-1) were strongly correlated with all the hematopoietic stem and progenitor concentrations examined (one standard-deviation increase in IGF-1 being associated with a 15-19% increase in stem/progenitor concentrations, all P < 0.02). Estriol and insulin-like growth factor binding protein-3 levels were positively and significantly correlated with some of these cell populations. Sex hormone-binding globulin levels were negatively correlated with these stem/progenitor pools. These relationships were stronger in Caucasians and Hispanics and were weaker or not present in Asian-Americans and African-Americans.
conclusionOur data support the concept that in utero mitogens may drive the expansion of stem cell populations. The correlations with IGF-1 and estrogen are noteworthy, as both are crucial for mammary gland development.
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