ArticlePLoS genetics2007
Y chromosome lineage- and village-specific genes on chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan.
Article in PLoS genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- From visceral to visible: A systematic review and meta-analysis of post-kala-azar dermal leishmaniasis incidence, risk factors, and treatment outcomes in Eastern Africa.PLoS neglected tropical diseases · 2026Pooled it
- Racism is not about "race".Scientific reports · 2023Article
- Individualized Medicine in Africa: Bringing the Practice Into the Realms of Population Heterogeneity.Frontiers in genetics · 2022Article
- Genetic diversity of the Sudanese: insights on origin and implications for health.Human molecular genetics · 2021Review
- The Y chromosome ancestry marker R1b1b2: a surrogate of the SARS-CoV-2 population affinity.Human genome variation · 2021Article
- Outbreaks and Outgroups: Three Tests of the Relationship Between Disease Avoidance Motives and Xenophobia During an Emerging Pandemic.Evolutionary psychological science · 2021Article
- Epitope-Binding Characteristics for Risk versus Protective DRB1 Alleles for Visceral Leishmaniasis.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Comprehensive candidate gene analysis for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil.Annals of human genetics · 2017Article
- Fine mapping under linkage peaks for symptomatic or asymptomatic outcomes of Leishmania infantum infection in Brazil.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Immune regulation during chronic visceral leishmaniasis.PLoS neglected tropical diseases · 2014Review
- Consanguinity, endogamy, and genetic disorders in Tunisia.Journal of community genetics · 2013Article
- Genetic and functional evaluation of the role of DLL1 in susceptibility to visceral leishmaniasis in India.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Article
- Genetic control of canine leishmaniasis: genome-wide association study and genomic selection analysis.PloS one · 2012Article
- Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis.PloS one · 2012Article
- Parasite stress promotes homicide and child maltreatment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Genetic and functional evidence implicating DLL1 as the gene that influences susceptibility to visceral leishmaniasis at chromosome 6q27.The Journal of infectious diseases · 2011Article
- Article
- Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases.Proceedings of the National Academy of Sciences of the United States of America · 2010Review
- Genetic admixture in Brazilians exposed to infection with Leishmania chagasi.Annals of human genetics · 2009Article
- Genetics and visceral leishmaniasis: of mice and man.Parasite immunology · 2009Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major susceptibility gene on Chromosome 22q12 in the Aringa ethnic group in Sudan. We now report a genome-wide scan using 69 families with 173 affected relatives from two villages occupied by the related Masalit ethnic group. A primary ten-centimorgan scan followed by refined mapping provided evidence for major loci at 1p22 (LOD score 5.65; nominal p = 1.72 x 10(-7); empirical p < 1 x 10(-5); lambdaS = 5.1) and 6q27 (LOD score 3.74; nominal p = 1.68 x 10(-5); empirical p < 1 x 10(-4); lambdaS = 2.3) that were Y chromosome-lineage and village-specific. Neither village supported a visceral leishmaniasis susceptibility gene on 22q12. The results suggest strong lineage-specific genes due to founder effect and consanguinity in these recently immigrant populations. These chance events in ethnically uniform African populations provide a powerful resource in the search for genes and mechanisms that regulate this complex disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.