ArticleJournal of insect physiology2007
Molecular aspects of transferrin expression in the tsetse fly (Glossina morsitans morsitans).
Article in Journal of insect physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Functional Divergence of the N-Lobe and C-Lobe ofAnimals : an open access journal from MDPI · 2022Article
- Warm Blood Meal Increases Digestion Rate and Milk Protein Production to Maximize Reproductive Output for the Tsetse Fly,Insects · 2022Article
- Suppression ofInsects · 2020Article
- Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.Genome biology · 2019Article
- Gene expression in reproductive organs of tsetse females - initial data in an approach to reduce fecundity.BMC microbiology · 2018Article
- Rapid autophagic regression of the milk gland during involution is critical for maximizing tsetse viviparous reproductive output.PLoS neglected tropical diseases · 2018Article
- Molecular characterization of tsetse's proboscis and its response to Trypanosoma congolense infection.PLoS neglected tropical diseases · 2017Article
- The immune properties of Manduca sexta transferrin.Insect biochemistry and molecular biology · 2017Article
- Mating-Induced Transcriptome Changes in the Reproductive Tract of Female Aedes aegypti.PLoS neglected tropical diseases · 2016Article
- A transferrin gene associated with development and 2-tridecanone tolerance in Helicoverpa armigera.Insect molecular biology · 2015Article
- Adenotrophic viviparity in tsetse flies: potential for population control and as an insect model for lactation.Annual review of entomology · 2015Review
- RNA-seq de novo Assembly Reveals Differential Gene Expression in Glossina palpalis gambiensis Infected with Trypanosoma brucei gambiense vs. Non-Infected and Self-Cured Flies.Frontiers in microbiology · 2015Article
- Trypanosome Transmission Dynamics in Tsetse.Current opinion in insect science · 2014Article
- Vitamin B6 generated by obligate symbionts is critical for maintaining proline homeostasis and fecundity in tsetse flies.Applied and environmental microbiology · 2014Article
- Aquaporins are critical for provision of water during lactation and intrauterine progeny hydration to maintain tsetse fly reproductive success.PLoS neglected tropical diseases · 2014Article
- A novel highly divergent protein family identified from a viviparous insect by RNA-seq analysis: a potential target for tsetse fly-specific abortifacients.PLoS genetics · 2014Article
- The homeodomain protein ladybird late regulates synthesis of milk proteins during pregnancy in the tsetse fly (Glossina morsitans).PLoS neglected tropical diseases · 2014Article
- Amelioration of reproduction-associated oxidative stress in a viviparous insect is critical to prevent reproductive senescence.PloS one · 2014Article
- Midgut expression of immune-related genes in Glossina palpalis gambiensis challenged with Trypanosoma brucei gambiense.Frontiers in microbiology · 2014Article
- Juvenile hormone and insulin suppress lipolysis between periods of lactation during tsetse fly pregnancy.Molecular and cellular endocrinology · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Iron is an essential element for metabolic processes intrinsic to life, and yet the properties that make iron a necessity also make it potentially deleterious. To avoid harm, iron homeostasis is achieved via proteins involved in transport and storage of iron, one of which is transferrin. We describe the temporal and spatial aspects of transferrin (GmmTsf) expression and its transcriptional regulation in tsetse where both the male and female are strictly hematophagous. Using Northern, Western and immunohistochemical analysis, we show that GmmTsf is abundant in the hemolymph and is expressed in the adult developmental stages of male and female insects. It is preferentially expressed in the female milk gland tubules and its expression appears to be cyclical and possibly regulated in synchrony with the oogenic and/or larvigenic cycle. Although no mRNA is detected, GmmTsf protein is present in the immature stages of development, apparently being transported into the intrauterine larva from the mother via the milk gland ducts. Transferrin is also detected in the vitellogenic ovary and the adult male testes, further supporting its classification as a vitellogenic protein. Similar to reports in other insects, transferrin mRNA levels increase upon bacterial challenge in tsetse suggesting that transferrin may play an additional role in immunity. Although transferrin expression is induced following bacterial challenge, it is significantly reduced in tsetse carrying midgut trypanosome infections. Analysis of tsetse that have cured the parasite challenge shows normal levels of GmmTsf. This observation suggests that the parasite in competing for the availability of limited dietary iron may manipulate host gene expression.
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