ArticleWorld journal of surgical oncology2007
Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship?
Article in World journal of surgical oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Association BetweenFrontiers in medicine · 2021Pooled it
- Association between Helicobacter pylori infection and the risk of colorectal cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Risk for Colorectal Neoplasia in Patients With Helicobacter pylori Infection: A Systematic Review and Meta-analysis.Clinical and translational gastroenterology · 2020Pooled it
- Helicobacter pylori infection and inflammatory bowel disease in Asians: a meta-analysis.World journal of gastroenterology · 2015Pooled it
- Helicobacter pylori infection increases the risk of colorectal adenomas: cross-sectional study and meta-analysis.Digestive diseases and sciences · 2012Pooled it
- Preventive Effect of Helicobacter pylori Treatment on Colorectal Cancer Incidence and Mortality.Journal of gastroenterology and hepatology · 2026Article
- Beyond the Stomach: Exploring the Role ofExpert reviews in molecular medicine · 2026Review
- Assessment of Fecal Microbiota in Healthy Dogs and Dogs with Cutaneous Mast Cell Tumors Treated with Electrochemotherapy Combined with Gene Electrotransfer of IL-12.Veterinary sciences · 2026Article
- Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection.International journal of molecular sciences · 2025Review
- Characterization of three gut microbes and their toxins in cancerous and healthy tissues of Iranian patients with colorectal cancer.Gastroenterology and hepatology from bed to bench · 2025Article
- Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Review
- The Association between Helicobacter pylori and Colorectal Neoplasia.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023Article
- Prevalence of Helicobacter pylori among Sudanese patients diagnosed with colon polyps and colon cancer using immunohistochemistry technique.BMC research notes · 2020Article
- Laparoscopic radical resection of gastric cancer and metachronous colon cancer-a case report.Translational cancer research · 2020Article
- Endoscopic gastric mucosal atrophy as a predictor of colorectal polyps: a large scale case-control study.Journal of clinical biochemistry and nutrition · 2019Article
- Helicobacter pylori and colorectal cancer-A bacterium going abroad?PLoS pathogens · 2019Article
- Role of gut microbiota in the pathogenesis of colorectal cancer; a review article.Gastroenterology and hepatology from bed to bench · 2018Review
- Colonic Abnormalities in Manitoban Children withGastroenterology research and practice · 2018Article
- Characterization of the fecal and mucosa-associated microbiota in dogs with colorectal epithelial tumors.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis pilot study was carried out to determine whether Helicobacter pylori can be detected in normal colon or in association with colorectal neoplasia.
methodsParaffin processed colonic tissue blocks of normal colonic mucosa (n = 60), and patients diagnosed as adenoma (n = 60), and adenocarcinoma (n = 60) were retrieved from our archive; the adenoma group included tubular (n = 20), tubulovillous (n = 20) and villous adenomas (n = 20). 4 mum sections were stained by immunohistochemical methods using anti-Helicobacter pylori antibodies (polyclonal NCL-HPp and monoclonal NCL-C-jejuni).
resultsSignificant numbers of Helicobacter pylori were identified in tubular adenomas (OR = 11.13; 95%CI = 1.62-76.70), tubulovillous adenomas (OR = 10.45; 95%CI = 1.52-71.52) and adenocarcinomas (OR = 8.13; 95%CI = 1.40-46.99) compared to controls: there was no association in numbers of Helicobacter pylori and villous adenomas (OR = 2.95; 95%CI = 0.29-9.96).
conclusionWe conclude that although, in this pilot study, there appears to be an association in the prevalence of Helicobacter pylori with some, but not all, colorectal neoplasms, we can not infer causality from these results. These findings need to be further substantiated with a prospective study and the use of molecular biological techniques to determine a causal association.
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