ArticleBMC genetics2007
Demographic changes and marker properties affect detection of human population differentiation.
Article in BMC genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
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- Leaves imitate trees: Minnesota Hmong concepts of heredity and applications to genomics research.Journal of community genetics · 2017Article
- Forensic STR loci reveal common genetic ancestry of the Thai-Malay Muslims and Thai Buddhists in the deep Southern region of Thailand.Journal of human genetics · 2014Article
- Ethnic and genetic factors in methadone pharmacokinetics: a population pharmacokinetic study.Drug and alcohol dependence · 2014Article
- Insight into the peopling of Mainland Southeast Asia from Thai population genetic structure.PloS one · 2013Article
- Human neutral genetic variation and forensic STR data.PloS one · 2012Article
- Molecular insights into the historic demography of bowhead whales: understanding the evolutionary basis of contemporary management practices.Ecology and evolution · 2012Article
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- Southeast Asian origins of five Hill Tribe populations and correlation of genetic to linguistic relationships inferred with genome-wide SNP data.American journal of physical anthropology · 2011Article
- CoAIMs: a cost-effective panel of ancestry informative markers for determining continental origins.PloS one · 2010Article
- Detecting signatures of inter-regional and inter-specific hybridization among the Chinese rhesus macaque specific pathogen-free (SPF) population using single nucleotide polymorphic (SNP) markers.Journal of medical primatology · 2010Article
- Identification of population substructure among Jews using STR markers and dependence on reference populations included.BMC genetics · 2010Article
- NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults.Depression and anxiety · 2010Article
- Variation in RGS2 is associated with suicidal ideation in an epidemiological study of adults exposed to the 2004 Florida hurricanes.Archives of suicide research : official journal of the International Academy for Suicide Research · 2009Article
- Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4.Genomics · 2008Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDifferentiating genetically between populations is valuable for admixture and population stratification detection and in understanding population history. This is easy to achieve for major continental populations, but not for closely related populations. It has been claimed that a large marker panel is necessary to reliably distinguish populations within a continent. We investigated whether empirical genetic differentiation could be accomplished efficiently among three Asian populations (Hmong, Thai, and Chinese) using a small set of highly variable markers (15 tetranucleotide and 17 dinucleotide repeats).
resultsHmong could be differentiated from Thai and Chinese based on multi-locus genotypes, but Thai and Chinese were indistinguishable from each other. We found significant evidence for a recent population bottleneck followed by expansion in the Hmong that was not present in the Thai or Chinese. Tetranucleotide repeats were less useful than dinucleotide repeat markers in distinguishing between major continental populations (Asian, European, and African) while both successfully distinguished Hmong from Thai and Chinese.
conclusionDemographic history contributes significantly to robust detection of intracontinental population structure. Populations having experienced a rapid size reduction may be reliably distinguished as a result of a genetic drift -driven redistribution of population allele frequencies. Tetranucleotide markers, which differ from dinucleotide markers in mutation mechanism and rate, are similar in information content to dinucleotide markers in this situation. These factors should be considered when identifying populations suitable for gene mapping studies and when interpreting interpopulation relationships based on microsatellite markers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.