ArticleMediators of inflammation2007
Tumor necrosis factor-alpha and interleukin 6 in human periapical lesions.
Article in Mediators of inflammation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Is there any association between the presence of biomarkers and apical periodontitis? A systematic review.Frontiers in immunology · 2024Pooled it
- Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review.Mediators of inflammation · 2015Pooled it
- Review
- Inflammatory mediators' essence in apical periodontitis.European oral research · 2024Article
- Accuracy of Gingival Crevicular Fluid Biomarkers of MMP8, TIMP1, RANK, RANKL, and OPG in Differentiating Symptomatic and Asymptomatic Apical Periodontitis.Diagnostics (Basel, Switzerland) · 2024Article
- Comparision of interleukin-1β concentrations in posttreatment endodontic disease and other pulpal and periapical conditions - A clinical study.Journal of conservative dentistry and endodontics · 2024Article
- Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease?Odontology · 2023Article
- Wnt7b: Is It an Important Factor in the Bone Formation Process after Calvarial Damage?Journal of clinical medicine · 2023Article
- Understanding painful versus non-painful dental pain in female and male patients: A transcriptomic analysis of human biopsies.PloS one · 2023Article
- Gene expression analysis of toll like receptor 2 and 4, Dectin-1, Osteopontin and inflammatory cytokines in human dental pulp ex-vivo.BMC oral health · 2022Article
- Revisiting the role of IL-1 signaling in the development of apical periodontitis.Frontiers in dental medicine · 2022Article
- Localization of interleukin-6 signaling complex in epithelialized apical lesions of endodontic origin.Clinical oral investigations · 2021Article
- Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis.Clinical oral investigations · 2020Article
- Electronic Cigarette Aerosol Modulates the Oral Microbiome and Increases Risk of Infection.iScience · 2020Article
- Elevated Expression of Macrophage Migration Inhibitory Factor Promotes Inflammatory Bone Resorption Induced in a Mouse Model of Periradicular Periodontitis.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Pro-inflammatory and anti-inflammatory cytokine expression in post-treatment apical periodontitis.Journal of applied oral science : revista FOB · 2018Article
- Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin.Clinical oral investigations · 2017Article
- Interleukin-6 expression on inflamed rat dental pulp tissue after capped withSaudi journal of biological sciences · 2017Article
- Salivary and serum interleukin-6 levels in proliferative verrucous leukoplakia.Clinical oral investigations · 2016Article
- The role of prophylactic ibuprofen and N-acetylcysteine on the level of cytokines in periapical exudates and the post-treatment pain.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions. SUBJECTS AND
methodsSamples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a control.
resultsTNF-alpha levels were significantly increased in symptomatic lesions compared to control. Group with asymptomatic lesions had significantly higher concentrations compared to control. There were no significant differences in TNF-alpha levels between symptomatic and asymptomatic lesions. In group with symptomatic lesions, IL-6 levels were significantly higher than in group with asymptomatic lesions. The IL-6 levels in symptomatic group also showed significantly higher concentration in comparison with control group. In asymptomatic group, the IL-6 level had significantly higher concentrations compared to control.
conclusionThese results indicate that symptomatic lesions represent an immunologically active stage of disease, and asymptomatic lesions are the point from which the process advances toward healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.