ArticleMediators of inflammation2007
Th1/Th2 cytokine ratio in tissue transudates from patients with oral lichen planus.
Article in Mediators of inflammation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Inflammatory cytokines and oral lichen planus: a Mendelian randomization study.Frontiers in immunology · 2024Pooled it
- A Systematic Review of Interleukin-17 in Oral Lichen Planus: From Etiopathogenesis to Treatment.Clinical medicine & research · 2023Pooled it
- Role of interleukin-4 in pathogenesis of oral lichen planus: A systematic review.Medicina oral, patologia oral y cirugia bucal · 2020Pooled it
- Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- The Use of Janus Kinase Inhibitors for Lichen Planus: An Evidence-Based Review.Journal of cutaneous medicine and surgeryPooled it
- Assessment of Salivary Interleukin-6 and Cortisol Levels in Patients with Oral Lichen Planus: A Biochemical Correlation with Clinical Severity.Journal of pharmacy & bioallied sciences · 2025Article
- The Potential Roles of IL-1β, IL-6, and RIPK3 in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.Diagnostics (Basel, Switzerland) · 2025Article
- Crosstalk Between Keratinocytes and T Cells in Ulcerative Oral Mucosal Diseases: Mechanisms of Epithelial Dysfunction and Therapeutic Perspectives.Journal of inflammation research · 2025Review
- Potential applications and mechanisms of natural products in mucosal-related diseases.Frontiers in immunology · 2025Review
- Article
- Vitamin D in the Treatment of Oral Lichen Planus: A Systematic Review.Biomedicines · 2022Review
- A Comparison of the Characteristics of Cytokine Storm between Lichen Planus and Oral Squamous Cell Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Gold Dental Implant-Induced Oral Lichen Planus.Cureus · 2022Article
- Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms ofJournal of oncology · 2022Article
- Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study.Cancer medicine · 2018Article
- MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2).Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women.Cancer management and research · 2018Article
- Serum cytokine profile and clinicopathological findings in oral lichen planus, oral lichenoid lesions and stomatitis.Clinical and experimental dental research · 2017Article
- Article
- The presence of bacteria within tissue provides insights into the pathogenesis of oral lichen planus.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe characteristics of oral lichen planus (OLP) provoke investigators to explore possible biomarkers by which to monitor disease activity and therapeutic efficacy. Oral fluids may provide an accessible medium for analysis of such biomarkers. Previous studies have shown that activation of nuclear factor-kappa B (NF-kappa B) plays an important role in the pathogenesis of oral lichen planus (OLP), which is a chronic inflammatory disorder mediated by T cells. Prior to the present investigation, reports of the levels of NF-kappa B and its dependent cytokines in oral fluids have not been forthcoming. The purpose of this study was to detect the level of NF-kappa B dependent cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in tissue transudates directly from lesions of OLP, and explore the feasibility of the data for clinical application. STUDY
designThirteen definitively diagnosed OLP subjects were enrolled in the study as were 13 age-sex matched controls. In each subject, lesion tissue transudates (TTs) were collected by a novel collection technique with a filter paper. The level of cytokines, TNF-alpha, IL-1-alpha, IL-6, and IL-8 in three types of oral fluids were determined by ELISA.
resultsIn the tissue transudate(TT), there were significantly higher level of cytokines TNF-alpha, IL-1-alpha, IL-6, and IL-8 detected in OLP patients than in controls: (TT: 40.0 +/- 9.8 versus 4.5 +/- 0.7, 710 +/- 114 versus 305 +/- 78, 150 +/- 25 versus 1.7 +/- 0.5, 2800 +/- 260 versus 1450 +/- 130, P < .0001; unit: pg/mL).
conclusionsThese results indicate that NF-kappa B dependent inflammatory cytokines may be detected at increased levels in oral lesion tissue transudates which may have diagnostic and prognostic potentials for monitoring disease activity and making therapeutic decisions in patients with OLP.
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Registered trials
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