ReviewOncogene2007
Systems biology analysis of G protein and MAP kinase signaling in yeast.
Review in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Evolutionary Stability of Small Molecular Regulatory Networks That Exhibit Near-Perfect Adaptation.Biology · 2023Article
- Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal virulence against insects.Science China. Life sciences · 2021Article
- Genetic behavioral screen identifies an orphan anti-opioid system.Science (New York, N.Y.) · 2019Article
- Quantitative analysis of the yeast pheromone pathway.Yeast (Chichester, England) · 2019Article
- A shadow detector for photosynthesis efficiency.Journal of theoretical biology · 2017Article
- Article
- Physiological, pathological, and structural implications of non-enzymatic protein-protein interactions of the multifunctional human transglutaminase 2.Cellular and molecular life sciences : CMLS · 2015Review
- Macromolecular networks and intelligence in microorganisms.Frontiers in microbiology · 2014Article
- Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.The Journal of biological chemistry · 2013Article
- Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling.Molecular systems biology · 2012Article
- Stochastic adaptation and fold-change detection: from single-cell to population behavior.BMC systems biology · 2011Article
- From Physics to Pharmacology?Reports on progress in physics. Physical Society (Great Britain) · 2011Article
- The effects of replacing Sst2 with the heterologous RGS4 on polarization and mating in yeast.Biophysical journal · 2010Article
- Harmonic oscillations in homeostatic controllers: Dynamics of the p53 regulatory system.Biophysical journal · 2010Article
- The control of the controller: molecular mechanisms for robust perfect adaptation and temperature compensation.Biophysical journal · 2009Article
- Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis.Current biology : CB · 2008Article
- Quantification of local morphodynamics and local GTPase activity by edge evolution tracking.PLoS computational biology · 2008Article
- Four-dimensional dynamics of MAPK information processing systems.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the treatment of human disease. However, the complexity of G protein signaling mechanisms has significantly hampered our ability to identify additional new drug targets. Moreover, today's molecular pharmacologists are accustomed to working on narrowly focused problems centered on a single protein or enzymatic process. Here we describe emerging efforts in yeast aimed at identifying proteins and processes that modulate the function of receptors, G proteins and MAP kinase effectors. The scope of these efforts is far more systematic, comprehensive and quantitative than anything attempted previously, and includes integrated approaches in genetics, proteomics and computational biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.