ArticleEMBO reports2007
Transport of the leaderless protein Ku on the cell surface of activated monocytes regulates their migratory abilities.
Article in EMBO reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.Nature communications · 2018Article
- DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion.Cell cycle (Georgetown, Tex.) · 2015Article
- Multifunctional proteins revealed by overlapping clustering in protein interaction network.Bioinformatics (Oxford, England) · 2012Article
- Article
- The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.PloS one · 2011Article
- Unconventional secretion of AcbA in Dictyostelium discoideum through a vesicular intermediate.Eukaryotic cell · 2010Article
- Adherence to and invasion of host cells by spotted Fever group rickettsia species.Frontiers in microbiology · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence shows that the DNA repair protein Ku is expressed on the surface of a subset of cells, where it contributes to adhesion and invasion processes, and also to viral or bacterial entry into target cells. Here, we show that Ku was expressed on the cell surface during activation of human monocytes and that its expression was independent of the conventional endoplasmic reticulum (ER)/Golgi secretory pathway. Ku inhibition, by blocking antibodies, decreases the migration of monocytes on fibronectin and laminin. On activation, nuclear Ku seems to move to the periphery of the cell and it shows a punctuate staining in the cytoplasm. The cytoplasmic distribution of Ku was shown to be unaltered by brefeldin A. Protease protection experiments show that Ku is contained within vesicles in activated monocytes. These data support a new role for Ku in the migration of monocytes into tissues, which depends on a tightly regulated pathway of intracellular redistribution.
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