Evidence map›Paper›PMID 17496344›Full record

ReviewImmunologic research2007

LIGHT-related molecular network in the regulation of innate and adaptive immunity.

Yanhui Xu, Koji Tamada, Lieping Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yanhui XuMolecular Biology Graduate Program, Mayo Clinic College of Medicine, Rochester, MN, USA.
Koji Tamada
Lieping Chen
Johns Hopkins University · USSidney Kimmel Comprehensive Cancer Center · US

Funding

EXPERIMENTAL THERAPY OF CANCER BY COSTIMULATED IMMUNITYR01CA085721 · NCI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI CHEN, LIEPING · 2000 to 2010
$3.4M
CD137 Antibody for Cancer TherapyR01CA106861 · NCI · MAYO CLINIC · PI CHEN, LIEPING · 2004 to 2008
$1.9M
NCI NIH HHS CA 106861NCI NIH HHS CA 85721
6 · The paper itself

Abstract

The LIGHT-related molecular network is composed of at least seven interacting receptors and ligands. Recent studies reveal that this network has profound immune regulatory functions for both innate and adaptive immunity. Experimental data support the concept that this network may also play roles in the pathogenesis of human diseases including cancer, infection, transplantation tolerance, and autoimmune diseases. In this review, we attempt to dissect each molecular interaction in detail and assemble them in the context of their roles in the pathogenesis and possible therapeutic potential in human diseases.

Indexed as

Gene Expression RegulationImmunity, InnateSignal TransductionAnimalsAutoimmune DiseasesCommunicable DiseasesHumansLymphocyte ActivationMiceNeoplasmsReceptors, Tumor Necrosis Factor, Member 14T-LymphocytesTumor Necrosis Factor Ligand Superfamily Member 14Receptors, Tumor Necrosis Factor, Member 14Tumor Necrosis Factor Ligand Superfamily Member 14

Identifiers

PMID17496344
OpenAlexW2076847439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.