ReviewImmunologic research2007
Decoding IgE Fc receptors.
Review in Immunologic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Pathophysiological Drivers of Mast Cell Activation Syndrome and Implications for Treatment.Fortune journal of health sciences · 2026Article
- Acute Allergic Reactions and Severe Anaphylaxis: Underlying Causes, Management Strategies, and Future Directions.Archives of internal medicine research · 2026Article
- Immunological signature of chronic spontaneous urticaria (Review).Experimental and therapeutic medicine · 2022Review
- Review
- Status of serine tyrosine kinase at germline and expressional levels in asthma patients.Molecular biology research communications · 2019Article
- The role of basophils as innate immune regulatory cells in allergy and immunotherapy.Human vaccines & immunotherapeutics · 2018Review
- Prospects from systems serology research.Immunology · 2018Review
- Allergic Inflammation in Aspergillus fumigatus-Induced Fungal Asthma.Current allergy and asthma reports · 2015Review
- B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma.Cellular & molecular immunology · 2015Article
- Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.PloS one · 2014Article
- Pathogenic intracellular and autoimmune mechanisms in urticaria and angioedema.Clinical reviews in allergy & immunology · 2013Review
- In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis.Journal of molecular histology · 2013Article
- A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations.Molecular biology reports · 2012Article
- Intestinal epithelial barrier dysfunction in food hypersensitivity.Journal of allergy · 2012Article
- FCεRI gene promoter polymorphisms and total IgE levels in susceptibility to atopic dermatitis in Korea.Journal of Korean medical science · 2011Article
- SNPs in the FCER1A gene region show no association with allergic rhinitis in a Han Chinese population.PloS one · 2010Article
- Murine B cells regulate serum IgE levels in a CD23-dependent manner.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- CD23/FcεRII: molecular multi-tasking.Clinical and experimental immunology · 2010Review
- FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding.Immunogenetics · 2009Article
- Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha).Immunologic research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcepsilonRI and low-affinity FcepsilonRII (CD23). Allergeninduced IgE-occupied FcepsilonRI aggregation on the mast cell or basophil cell surface leads to the activation of intracellular signaling events and eventually the release of pre-formed and de novo synthesized inflammatory mediators. The role of FcepsilonRII in allergic diseases has been proposed to include regulation of IgE synthesis, enhanced histamine release from basophils, and a contribution to Ag-IgE complex presentation but the exact function of CD23 remains poorly understood. This review summarizes some new developments in IgE Fc-receptor studies with an emphasis on regulation of FcepsilonRI expression and signal transduction, including monomeric IgE, lipid raft segregation, and some recently identified negative regulators. A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.