ReviewBlood2007
Trousseau's syndrome: multiple definitions and multiple mechanisms.
Review in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 368 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
368 citing papers in PubMed, 4 syntheses or guidelines pooled it, 820 citations in OpenAlex.
- Cancer-associated Marantic Endocarditis and Direct Oral Anticoagulants: Case Report and Systematic Review.Current cardiology reviews · 2026Pooled it
- Ischemic stroke associated with adenomyosis-related abnormal uterine bleeding: a systematic review of management and outcomes.Frontiers in neurology · 2025Pooled it
- Prognosis of pancreatic cancer with Trousseau syndrome: a systematic review of case reports in Japanese literature.Journal of the Egyptian National Cancer Institute · 2023Pooled it
- Recurrent embolic stroke associated with adenomyosis: A single case report and literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Observational
- Increased Out-of-Hospital Cardiac Arrest Risk in Cancer: Evidence From 800,000 Patients and 3.7 Million Controls.JACC. Advances · 2026Article
- Cancer-Related Microangiopathic Haemolytic Anemia Revealing Occult Metastatic Gastrointestinal Signet-Ring Cell Carcinoma: A Clinicopathological Case Report and Practical Differential Diagnostic Approach.Clinical case reports · 2026Article
- Carcinoma of Unknown Primary Origin Presenting as Rapidly Progressive Multifocal Skeletal Lesions and Fatal Systemic Thrombosis in a Dog: A Case Report.Veterinary sciences · 2026Article
- Prostate cancer-associated Trousseau's syndrome presenting as stroke in a 42-year-old man.Urology case reports · 2026Article
- Mitral valve vegetations in an elderly patient with acute myeloid leukemia: navigating the overlap between infection and malignancy: a case report.Journal of medical case reports · 2026Article
- Systemic Immune-Inflammation Index, Thrombotic Status, and Mortality in Patients with Cancer: A Matched Cohort Study.Diseases (Basel, Switzerland) · 2026Article
- Fulminant disseminated carcinomatosis of the bone marrow from pancreatic mucinous carcinoma with predominant signet ring cell morphology.Clinical journal of gastroenterology · 2026Article
- Home Intravenous Heparin Therapy via a Central Venous Port for Recurrent Cancer-associated Stroke Requiring Repeat Mechanical Thrombectomy.Internal medicine (Tokyo, Japan) · 2026Article
- Clinical and prognostic insights into Trousseau's syndrome in gynecologic malignancies: a multicenter study.Journal of gynecologic oncology · 2026Article
- Hypercoagulability Predicts Survival and Reflects NET-Associated Thromboinflammation in Advanced Pancreatic Cancer.Cancers · 2026Article
- Trends and disparities for co-existent pancreatic cancer and cardiovascular-related deaths: a retrospective 1999-2020 analysis of CDC WONDER data.Cardio-oncology (London, England) · 2026Article
- Article
- [Embolic occlusions of the right hand: an interdisciplinary challenge].Innere Medizin (Heidelberg, Germany) · 2026Article
- Trousseau Syndrome Associated With Prostate Cancer: A Systematic Review of Case Reports.Cureus · 2026Review
- Superficial Venous Thrombosis in Non-Varicose Veins: A Narrative Review.Journal of clinical medicine · 2026Review
308 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In 1865, Armand Trousseau noted that unexpected or migratory thrombophlebitis could be a forewarning of an occult visceral malignancy. An analysis by Sack and colleagues in 1977 extended the term Trousseau's syndrome to include chronic disseminated intravascular coagulopathy associated with microangiopathy, verrucous endocarditis, and arterial emboli in patients with cancer, often occurring with mucin-positive carcinomas. In recent times the term has been ascribed to various clinical situations, ranging all the way from these classic descriptions to any kind of coagulopathy occurring in the setting of any kind of malignancy. These multiple definitions of Trousseau's syndrome are partly the consequence of multiple pathophysiologic mechanisms that apparently contribute to the hypercoagulability associated with cancer. Even the classic syndrome probably represents a spectrum of disorders, ranging from exaggerated fluid-phased thrombosis dependent on prothrombotic agents such as tissue factor to a platelet- and endotheliumum-based selectin-dependent microangiopathy associated with mucin-producing carcinomas, along with thrombin and fibrin production. Also considered here are recent hypotheses about genetic pathways within tumor cells that might trigger these thrombotic phenomena, and the reasons why therapy with heparins of various kinds remain the preferred treatment, probably because of their salutary actions on several of the proposed pathologic mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.