ArticleProceedings of the National Academy of Sciences of the United States of America2007
Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Evaluation of the effect of hemodynamic factors on retinal microcirculation by using 3D confocal image-based computational fluid dynamics.Frontiers in bioengineering and biotechnology · 2024Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Molecular Tension Probes to Quantify Cell-Generated Mechanical Forces.Molecules and cells · 2022Review
- Editorial: Understanding molecular interactions that underpin vascular mechanobiology.APL bioengineering · 2021Article
- Histopathologic findings of vascular damage after mechanical thrombectomy using stent retriever in canine models.Journal of thrombosis and thrombolysis · 2021Article
- Sinner or Saint?: Nck Adaptor Proteins in Vascular Biology.Frontiers in cell and developmental biology · 2021Review
- Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.Journal of the American Heart Association · 2020Article
- Endothelial mechanobiology.APL bioengineering · 2020Article
- Remodeling of the Microvasculature: May the Blood Flow Be With You.Frontiers in physiology · 2020Review
- Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible.Acta physiologica (Oxford, England) · 2016Article
- Diffusion phenomena of cells and biomolecules in microfluidic devices.Biomicrofluidics · 2015Article
- Mechanotransduction at focal adhesions: from physiology to cancer development.Journal of cellular and molecular medicine · 2013Review
- Shear stress during early embryonic stem cell differentiation promotes hematopoietic and endothelial phenotypes.Biotechnology and bioengineering · 2013Article
- Fluid forces control endothelial sprouting.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- X-linked inhibitor of apoptosis protein controls alpha5-integrin-mediated cell adhesion and migration.American journal of physiology. Heart and circulatory physiology · 2010Article
- Live cell imaging of mechanotransduction.Journal of the Royal Society, Interface · 2010Review
- Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics.Microcirculation (New York, N.Y. : 1994) · 2010Review
- Focal adhesion kinase phosphorylation in flow-activation of endothelial NF-kappaB. Focus on "Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells".American journal of physiology. Cell physiology · 2009Article
- Rapid signal transduction in living cells is a unique feature of mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes.FEBS letters · 2007Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Vascular endothelial cells are continuously exposed to mechanical and chemical stimuli, such as shear stress and VEGF, respectively. It is still not clear how cells perceive these stimuli and orchestrate their responses. Studying the molecular mechanism by which shear stress and VEGF regulate the signaling pathways in bovine endothelial aortic cells, we found that VEGF induced a rapid association of VEGF receptor 2 (Flk-1) with Nck beta, but shear stress did not have such an effect. SU1498 (a specific inhibitor of Flk-1) and Nck beta(nm) (a negative mutant of Nck beta) blocked the VEGF-induced ERK and JNK activities. Only SU1498, but not Nck beta(nm), inhibited the shear-induced ERK activity. Furthermore, neither SU1498 nor Nck beta(nm) had significant effects on the shear-induced JNK activity, which can be blocked by inhibitors of Src family kinase and ROCK kinase. Therefore, mechanical (shear stress) and chemical (VEGF) stimuli diverge at the receptor Flk-1 in terms of the recruitment of the adapter protein Nck beta, and they employ different components of the complex signaling network in regulating downstream molecules, e.g., ERK and JNK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.