ArticleProceedings of the National Academy of Sciences of the United States of America2007
Principal-components analysis of shape fluctuations of single DNA molecules.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Label-Free Anti-Brownian Trapping of Single Nanoparticles in Solution.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Solution properties of spherical gold nanoparticles with grafted DNA chains from simulation and theory.Nanoscale advances · 2022Article
- A Study on the Bending Stiffness of a New DNA Origami Nano-Joint.Molecular biotechnology · 2021Article
- Time-resolved multirotational dynamics of single solution-phase tau proteins reveals details of conformational variation.Physical chemistry chemical physics : PCCP · 2019Article
- Measurement of Mesoscale Conformational Dynamics of Freely Diffusing Molecules with Tracking FCS.Biophysical journal · 2018Article
- Feedback traps for virtual potentials.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Review
- Tracking Equilibrium and Nonequilibrium Shifts in Data with TREND.Biophysical journal · 2017Article
- Nanoscale devices for linkerless long-term single-molecule observation.Current opinion in biotechnology · 2016Review
- Dynamic properties of independent chromatin domains measured by correlation spectroscopy in living cells.Epigenetics & chromatin · 2016Article
- DNA motion capture reveals the mechanical properties of DNA at the mesoscale.Biophysical journal · 2015Article
- Single-molecule spectroscopy and imaging over the decades.Faraday discussions · 2015Review
- Genome-scale quantitative characterization of bacterial protein localization dynamics throughout the cell cycle.Molecular microbiology · 2015Article
- Role of microscopic flexibility in tightly curved DNA.The journal of physical chemistry. B · 2014Article
- Lab-on-a-chip technologies for single-molecule studies.Lab on a chip · 2013Article
- Fluctuation modes of nanoconfined DNA.Journal of applied physics · 2012Article
- Microfluidic systems for single DNA dynamics.Soft matter · 2012Article
- Conformational dynamics of single G protein-coupled receptors in solution.The journal of physical chemistry. B · 2011Article
- Redox cycling and kinetic analysis of single molecules of solution-phase nitrite reductase.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Density fluctuations dispersion relationship for a polymer confined to a nanotube.Applied physics letters · 2011Article
- Collapse of DNA in ac electric fields.Physical review letters · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Thermal fluctuations agitate molecules in solution over a broad range of times and distances. By passively watching the shape fluctuations of a thermally driven biomolecule, one can infer properties of the underlying interactions that determine the motion. We applied this concept to single molecules of fluorescently labeled lambda-DNA, a key model system for polymer physics. In contrast to most other single-molecule DNA experiments, we examined the unstretched, equilibrium state of DNA by using an anti-Brownian electrokinetic trap to confine the center of mass of the DNA without perturbing its internal dynamics. We analyze the long-wavelength conformational normal modes, calculate their spring constants, and measure linear and nonlinear couplings between modes. The modes show strong signs of nonlinear hydrodynamics, a feature of the underlying equations of polymer dynamics that has not previously been reported and is neglected in the widely used Rouse and Zimm approximations.
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