ArticleThe Plant cell2007
The two AGPase subunits evolve at different rates in angiosperms, yet they are equally sensitive to activity-altering amino acid changes when expressed in bacteria.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 63 citations in OpenAlex.
- Genome-Wide Analysis of AGPase IdentifiesInternational journal of molecular sciences · 2026Article
- Structure and mechanism of the heterotetrameric ADP-glucose pyrophosphorylase essential for starch synthesis in plants.Science advances · 2026Article
- Polyploidization-Driven Functional Innovation of AGPase Small Subunit GeneInternational journal of molecular sciences · 2026Article
- Amylopectin branch trimming and biosynthesis elucidated by the rice isoamylase ISA1-ISA2 heterocomplex.Nature communications · 2025Article
- Genome-Wide Comparative Analysis of Invertases in theCurrent issues in molecular biology · 2025Article
- Expression and interaction of AGPase subunits reveal functional enzyme complexes in barley.Frontiers in plant science · 2025Article
- ADP-glucose pyrophosphorylase gene family in soybean and implications in drought stress tolerance.Genes & genomics · 2024Article
- Architecture, Function, Regulation, and Evolution of α-Glucans Metabolic Enzymes in Prokaryotes.Chemical reviews · 2024Review
- Structure, function, and evolution of plant ADP-glucose pyrophosphorylase.Plant molecular biology · 2022Review
- Article
- Accumulation of starch in duckweeds (Lemnaceae), potential energy plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Review
- Article
- Abscisic acid-enhanced starch accumulation of bioenergy crop duckweed (RSC advances · 2020Article
- The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM.Current research in structural biology · 2020Article
- Unraveling the genetic architecture of grain size in einkorn wheat through linkage and homology mapping and transcriptomic profiling.Journal of experimental botany · 2019Article
- The Proteomic Analysis of Maize Endosperm Protein Enriched by Phos-tagInternational journal of molecular sciences · 2019Article
- Mechanism Underlying Heat Stability of the Rice Endosperm Cytosolic ADP-Glucose Pyrophosphorylase.Frontiers in plant science · 2019Article
- Evolutionary, structural and expression analysis of core genes involved in starch synthesis.Scientific reports · 2018Article
- An evolutionary model motivated by physicochemical properties of amino acids reveals variation among proteins.Bioinformatics (Oxford, England) · 2018Article
- ADP-glucose pyrophosphorylase genes, associated with kernel weight, underwent selection during wheat domestication and breeding.Plant biotechnology journal · 2017Article
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4 authors at 1 institution in 1 country.
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Abstract
The rate of protein evolution is generally thought to reflect, at least in part, the proportion of amino acids within the protein that are needed for proper function. In the case of ADP-glucose pyrophosphorylase (AGPase), this premise led to the hypothesis that, because the AGPase small subunit is more conserved compared with the large subunit, a higher proportion of the amino acids of the small subunit are required for enzyme activity compared with the large subunit. Evolutionary analysis indicates that the AGPase small subunit has been subject to more intense purifying selection than the large subunit in the angiosperms. However, random mutagenesis and expression of the maize (Zea mays) endosperm AGPase in bacteria show that the two AGPase subunits are equally predisposed to enzyme activity-altering amino acid changes when expressed in one environment with a single complementary subunit. As an alternative hypothesis, we suggest that the small subunit exhibits more evolutionary constraints in planta than does the large subunit because it is less tissue specific and thus must form functional enzyme complexes with different large subunits. Independent approaches provide data consistent with this alternative hypothesis.
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