ArticleJournal of bacteriology2007
Low concentrations of bile salts induce stress responses and reduce motility in Bacillus cereus ATCC 14579 [corrected].
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 95 citations in OpenAlex.
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- Phenotypic heterogeneity and pathogenicity of Listeria monocytogenes under complex salinities of bile salts and sodium salts stress.Archives of microbiology · 2025Article
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- Functional Characterization of Salmonella Typhimurium Encoded YciF, a Domain of Unknown Function (DUF892) Family Protein, and Its Role in Protection during Bile and Oxidative Stress.Journal of bacteriology · 2023Article
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- OmpC-Dependent Bile Tolerance Contributes to E. coli Colonization of the Mammalian Intestine.Microbiology spectrum · 2023Article
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- The cost of bacterial predation via type VI secretion system leads to predator extinction under environmental stress.iScience · 2021Article
- Lemon exosome-like nanoparticles enhance stress survival of gut bacteria by RNase P-mediated specific tRNA decay.iScience · 2021Article
- Analyzing Possible Native Functions of the Quinolone Resistance GeneAntimicrobial agents and chemotherapy · 2021Article
- Physiological and Genomic Analysis ofMicroorganisms · 2021Article
- TheMicrobiology (Reading, England) · 2021Article
- Exoproteome Perspective on the Bile Stress Response ofProteomes · 2021Article
- TheToxins · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tolerance to bile salts was investigated in forty Bacillus cereus strains, including 17 environmental isolates, 11 dairy isolates, 3 isolates from food poisoning outbreaks, and 9 other clinical isolates. Growth of all strains was observed at low bile salt concentrations, but no growth was observed on LB agar plates containing more than 0.005% bile salts. Preincubation of the B. cereus type strain, ATCC 14579, in low levels of bile salts did not increase tolerance levels. B. cereus ATCC 14579 was grown to mid-exponential growth phase and shifted to medium containing bile salts (0.005%). Global expression patterns were determined by hybridization of total cDNA to a 70-mer oligonucleotide microarray. A general stress response and a specific response to bile salts were observed. The general response was similar to that observed in cultures grown in the absence of bile salts but at a higher (twofold) cell density. Up-regulation of several putative multidrug exporters and transcriptional regulators and down-regulation of most motility genes were observed as part of the specific response. Motility experiments in soft agar showed that motility decreased following bile salts exposure, in accordance with the transcriptional data. Genes encoding putative virulence factors were either unaffected or down-regulated.
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