ArticleJournal of bacteriology2007
Effect of a recD mutation on DNA damage resistance and transformation in Deinococcus radiodurans.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Unraveling the Central Role of Global Regulator PprI inProteomes · 2025Article
- Comparative Genomics Revealed Wide Intra-Species Genetic Heterogeneity and Lineage-Specific Genes ofMicrobiology spectrum · 2022Article
- The RecD2 helicase balances RecA activities.Nucleic acids research · 2022Article
- Effects of Conserved Wedge Domain Residues on DNA Binding Activity ofFrontiers in genetics · 2021Article
- RecD2 helicase limits replication fork stress in Bacillus subtilis.Journal of bacteriology · 2014Article
- Oxidative stress resistance in Deinococcus radiodurans.Microbiology and molecular biology reviews : MMBR · 2011Review
- Kinetics of DNA unwinding by the RecD2 helicase from Deinococcus radiodurans.The Journal of biological chemistry · 2010Article
- A major role of the RecFOR pathway in DNA double-strand-break repair through ESDSA in Deinococcus radiodurans.PLoS genetics · 2010Article
- Endogenous nitric oxide regulates the recovery of the radiation-resistant bacterium Deinococcus radiodurans from exposure to UV light.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The evolution of RecD outside of the RecBCD complex.Journal of molecular evolution · 2009Article
- RecBCD enzyme and the repair of double-stranded DNA breaks.Microbiology and molecular biology reviews : MMBR · 2008Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The bacterium Deinococcus radiodurans is resistant to extremely high levels of DNA-damaging agents such as UV light, ionizing radiation, and chemicals such as hydrogen peroxide and mitomycin C. The organism is able to repair large numbers of double-strand breaks caused by ionizing radiation, in spite of the lack of the RecBCD enzyme, which is essential for double-strand DNA break repair in Escherichia coli and many other bacteria. The D. radiodurans genome sequence indicates that the organism lacks recB and recC genes, but there is a gene encoding a protein with significant similarity to the RecD protein of E. coli and other bacteria. We have generated D. radiodurans strains with a disruption or deletion of the recD gene. The recD mutants are more sensitive than wild-type cells to irradiation with gamma rays and UV light and to treatment with hydrogen peroxide, but they are not sensitive to treatment with mitomycin C and methyl methanesulfonate. The recD mutants also show greater efficiency of transformation by exogenous homologous DNA. These results are the first indication that the D. radiodurans RecD protein has a role in DNA damage repair and/or homologous recombination in the organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.