ArticleJournal of bacteriology2007
Histidine auxotrophy in commensal and disease-causing nontypeable Haemophilus influenzae.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Metabolism and gene sequence variation in Turicella otitidis implies its adaptability and pathogenicity in extra-otic infection: a systematic review.BMC infectious diseases · 2023Pooled it
- Role of Metabolic Adaptation ofPathogens (Basel, Switzerland) · 2023Review
- Article
- Learning from -omics strategies applied to uncoverComputational and structural biotechnology journal · 2021Review
- Do the human gut metagenomic species possess the minimal set of core functionalities necessary for life?BMC genomics · 2020Article
- Metabolic and genetic basis for auxotrophies in Gram-negative species.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Reconstruction and Validation of a Genome-Scale Metabolic Model ofFrontiers in genetics · 2020Article
- Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development.mSphere · 2018Article
- Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1.International journal of inflammation · 2017Article
- Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKβ pathway and up-regulation of negative MKP-1 pathway.Scientific reports · 2016Article
- Difficult identification of Haemophilus influenzae, a typical cause of upper respiratory tract infections, in the microbiological diagnostic routine.European journal of microbiology & immunology · 2015Review
- Otitis media associated polymorphisms in the hemin receptor HemR of nontypeable Haemophilus influenzae.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
- Comparative genomic analysis reveals distinct genotypic features of the emerging pathogen Haemophilus influenzae type f.BMC genomics · 2014Article
- Draft genome sequence of Turicella otitidis ATCC 51513, isolated from middle ear fluid from a child with otitis media.Journal of bacteriology · 2012Article
- Nontypeable Haemophilus influenzae genetic islands associated with chronic pulmonary infection.PloS one · 2012Article
- Article
- Prevalence of genetic differences in phosphorylcholine expression between nontypeable Haemophilus influenzae and Haemophilus haemolyticus.BMC microbiology · 2010Article
- Article
- Prevalence of Haemophilus influenzae type b genetic islands among clinical and commensal H. influenzae and H. haemolyticus isolates.Journal of clinical microbiology · 2010Article
- Prevalence of the sodC gene in nontypeable Haemophilus influenzae and Haemophilus haemolyticus by microarray-based hybridization.Journal of clinical microbiology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Histidine biosynthesis is one of the best studied metabolic pathways in bacteria. Although this pathway is thought to be highly conserved within and between bacterial species, a previous study identified a genetic region within the histidine operon (his) of nontypeable strains of Haemophilus influenzae (NTHI) that was more prevalent among otitis media strains than among throat commensal NTHI strains. In the present study, we further characterized this region and showed that genes in the complete his operon (hisG, -D, -C, -NB, -H, -A, -F, and -IE) are >99% conserved among four fully sequenced NTHI strains, are present in the same location in these four genomes, and are situated in the same gene order. Using PCR and dot blot hybridization, we determined that the his operon was significantly more prevalent in otitis media NTHI strains (106/121; 87.7%) than in throat strains (74/137; 54%) (prevalence ratio, 1.62; P<0.0001), suggesting a possible role in middle ear survival and/or acute otitis media. NTHI strains lacking the his operon showed attenuated growth in histidine-restricted media, confirming them as his-negative auxotrophs. Our results suggest that the ability to make histidine is an important factor in bacterial growth and survival in the middle ear, where nutrients such as histidine may be found in limited amounts. Those isolates lacking the histidine pathway were still able to survive well in the throat, which suggests that histidine is readily available in the throat environment.
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