ArticleBiophysical journal2007
Solute transport in growth plate cartilage: in vitro and in vivo.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- The Actions of IGF-1 in the Growth Plate and Its Role in Postnatal Bone Elongation.Current osteoporosis reports · 2020Review
- Live imaging analysis of the growth plate in a murine long bone explanted culture system.Scientific reports · 2018Article
- Regenerative Medicine Approaches for the Treatment of Pediatric Physeal Injuries.Tissue engineering. Part B, Reviews · 2018Review
- Imaging IGF-I uptake in growth plate cartilage using in vivo multiphoton microscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Altered paracrine signaling from the injured knee joint impairs postnatal long bone growth.eLife · 2017Article
- Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.Science signaling · 2016Article
- High-Resolution Methods for Diagnosing Cartilage Damage In Vivo.Cartilage · 2016Article
- In vivo fluorescence microscopy: lessons from observing cell behavior in their native environment.Physiology (Bethesda, Md.) · 2015Review
- Hindlimb heating increases vascular access of large molecules to murine tibial growth plates measured by in vivo multiphoton imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Identification of cartilage injury using quantitative multiphoton microscopy.Osteoarthritis and cartilage · 2014Article
- Article
- Phosphorescent nanoparticles for quantitative measurements of oxygen profiles in vitro and in vivo.Biomaterials · 2012Article
- Multiphoton fluorescence recovery after photobleaching in bounded systems.Physical review. E, Statistical, nonlinear, and soft matter physics · 2011Article
- Exercise mitigates the stunting effect of cold temperature on limb elongation in mice by increasing solute delivery to the growth plate.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Temperature alters solute transport in growth plate cartilage measured by in vivo multiphoton microscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Bone elongation originates from cartilaginous discs (growth plates) at both ends of a growing bone. Here chondrocytes proliferate and subsequently enlarge (hypertrophy), laying down a matrix that serves as the scaffolding for subsequent bone matrix deposition. Because cartilage is generally avascular, all nutrients, oxygen, signaling molecules, and waste must be transported relatively long distances through the tissue for it to survive and function. Here we examine the transport properties of growth plate cartilage. Ex vivo, fluorescence photobleaching recovery methods are used in tissue explants. In vivo, multiphoton microscopy is used to image through an intact perichondrium and into the cartilage of anesthetized mice. Systemically introduced fluorescent tracers are monitored directly as they move from the vasculature into the cartilage. We demonstrate the existence of a relatively permissive region at the midplane of the growth plate, where chondrocytes transition from late proliferative to early hypertrophic stages and where paracrine communication is known to occur between chondrocytes and cells in the surrounding perichondrium. Transport in the living mouse is also significantly affected by fluid flow from the two chondro-osseus junctions, presumably resulting from a pressure difference between the bone vasculature and the cartilage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.