ArticleBiophysical journal2007
Gold-nanoparticle-assisted laser perturbation of chromatin assembly reveals unusual aspects of nuclear architecture within living cells.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Growth-Stimulating Effect of Platelet Lysates Obtained with Low-Pulse Laser Radiation in Human Fibroblast Culture.Bulletin of experimental biology and medicine · 2025Article
- Peripheral heterochromatin tethering is required for chromatin-based nuclear mechanical response.Nucleic acids research · 2025Article
- Quantifying Nuclear Structures of Digital Pathology Images Across Cancers Using Transport-Based Morphometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2025Article
- Femtosecond Plasmonic Laser Nanosurgery (fs-PLN) mediated by molecularly targeted gold nanospheres at ultra-low pulse fluences.Scientific reports · 2020Article
- Epigenetic Aspects of Engineered Nanomaterials: Is the Collateral Damage Inevitable?Frontiers in bioengineering and biotechnology · 2019Review
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.Chemical reviews · 2018Review
- Regulation of genome organization and gene expression by nuclear mechanotransduction.Nature reviews. Molecular cell biology · 2017Review
- Nuclear morphologies: their diversity and functional relevance.Chromosoma · 2017Review
- Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner.Scientific reports · 2016Article
- Nuclear deformability and telomere dynamics are regulated by cell geometric constraints.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes.Experimental biology and medicine (Maywood, N.J.) · 2015Article
- Condensins exert force on chromatin-nuclear envelope tethers to mediate nucleoplasmic reticulum formation in Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- Biodegradable and multifunctional polymer micro-tubes for targeting photothermal therapy.International journal of molecular sciences · 2014Article
- Actomyosin contractility rotates the cell nucleus.Scientific reports · 2014Article
- Correlated spatio-temporal fluctuations in chromatin compaction states characterize stem cells.Biophysical journal · 2013Article
- Mechanosensitive mechanisms in transcriptional regulation.Journal of cell science · 2012Review
- Nuclear mechanics in disease.Annual review of biomedical engineering · 2011Review
- Integrin adhesion drives the emergent polarization of active cytoskeletal stresses to pattern cell delamination.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Nanotopographical control of stem cell differentiation.Journal of tissue engineering · 2010Article
- Emergence of a prestressed eukaryotic nucleus during cellular differentiation and development.Journal of the Royal Society, Interface · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromatin organization within the nucleus is a vital regulator of genome function, yet its mechanical coupling to the nuclear architecture has remained elusive. To directly investigate this coupling, we locally modulated chromatin structure in living cells using nanoparticle-based laser perturbation. Unusual differences in the response of the cell nucleus were observed depending on the nuclear region that was perturbed--the heterochromatin, the euchromatin, and the nuclear envelope. This response varied under different conditions of cellular perturbations such as ATP depletion, apoptosis, and inhibition of histone deacetylases. Our studies implicate heterochromatin organization in imparting mechanical stability to the cell nucleus and suggest that nuclear size and shape are the result of interplay between nuclear and cytoplasmic anchors.
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