ArticleBiophysical journal2007
External K activation of Kir1.1 depends on the pH gate.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Regulation of BK-α expression in the distal nephron by aldosterone and urine pH.American journal of physiology. Renal physiology · 2013Article
- Protein kinase C mediated pH(i)-regulation of ROMK1 channels via a phosphatidylinositol-4,5-bisphosphate-dependent mechanism.Journal of molecular modeling · 2012Article
- Residues at the outer mouth of Kir1.1 determine K-dependent gating.Biophysical journal · 2012Article
- Potassium-dependent activation of Kir4.2 K⁺ channels.The Journal of physiology · 2011Article
- Modulation of Kir1.1 inactivation by extracellular Ca and Mg.Biophysical journal · 2011Article
- Inward rectifier channel, ROMK, is localized to the apical tips of glial-like cells in mouse taste buds.The Journal of comparative neurology · 2009Article
- An intersubunit salt bridge near the selectivity filter stabilizes the active state of Kir1.1.Biophysical journal · 2009Article
- A conserved arginine near the filter of Kir1.1 controls Rb/K selectivity.Channels (Austin, Tex.)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The inward rectifier Kir1.1 (ROMK) family is gated by both internal pH and external K, where the putative pH gate is formed by the convergence of leucine side chains, near the inner helical bundle crossing at L160-Kir1.1. However, it is unclear whether K activation is mediated at the pH gate or by another gate in the permeation path. In this study, we used the whole-cell conductance increase during rapid K elevation as a measure of K activation, assuming that activation is inherently slower than changes in channel conduction. Results indicate that structural disruption of the Kir1.1 bundle-crossing pH gate prevents both inactivation by low external K and reactivation by high external K.
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Registered trials
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